半夏泻心汤合丹参饮治疗胃心综合征疗效评价

Evaluation on curative effect of Banxia xiexin decoction combined with Danshen decoction in treating gastrocardiac syndrome

[目的]观察半夏泻心汤合丹参饮治疗胃心综合征,并评价其循证医学治疗性疗效。[方法]经预实验获得94例样本量,按患者就诊序号,随机分为A组和B组各47例。A组给予半夏泻心汤合丹参饮,B组给予奥美拉唑肠溶片、颠茄片、丹参片,2组观察周期均为15d,观察2组综合疗效,疗效积分,并评价其比值比(OR)、相对危险度(RR)、相对危险度降低率(RRR)、绝对危险度降低率(ARR)、需要治疗的病例数(NNT)及其95%的可信区间(CI)。[结果]A组、B组的综合疗效分别为100.0%、82.9%,A组治疗后的症状、体征及心电图的积分较B组明显改善(P<0.05及0.01);A组的OR=10.0,OR95%CI=3.4～15.6;RR=0.43,RR95%CI=0.09～0.72;RRR=57.0%,RRR95%CI=28.0%～91.0%;ARR=23.4%,ARR95%CI=5.2%～32.0%;NNT=4,NNT95%CI=3～5(例)。2组在观察期间均未出现不良事件,治疗后检查肝、肾功能均无异常。[结论]半夏泻心汤合丹参饮治疗胃心综合征疗效好;循证医学治疗性疗效评价其优于奥美拉唑肠溶片、颠茄片、丹参片联合治疗。

[Objective]To observethe curative effect of Banxia xiexin decoction combined with Danshen decoction in treating gastrocardiac syndrome. [Method] Ninety-four cases were crucuited by preliminary experiment and divided into observation group and control group at random according to their appointment order,47 cases in each group. Banxia xiexin decoction combined with Dansen decoction was given to the observation group while the control group was administered with restraining acid, arresting convulsions, and promoting blood circulation to remove blood stasis. The treatment period was 15 days. Curative effect was observed and the odds ratio （OR）, relative risk（RR）, relative risk reduction（RRR）, absolute risk re- duction （ARR）,number needed to treat （NNT） and its 95% credibility interval （CI） were evaluated re- spectively. [Result] Compared with the control group, the comprehensive curative effect of Banxia xiexin decoction combined with Danshen decoction was significantly higher （100.00% vs 82.9%）;the scores of symptoms, signs and electrocardiogram in the observation group were significantly improved （P〈0.05, or P〈0. 01）. Neither of the two groups resulted in adverse events. The examination of the liver and renal function showed no abnormalities after the treatment. [Conclusion]Banxia xiexin decoction combined with Danshen decoction had good effect in treating gastrocardiac syndrome, and the assessment of curative effect in evidence-based medicine showed its superiority to conventional Chinese and western medicine treatment.