神经干细胞移植治疗耐药性颞叶癫癎研究进展
摘要
癫癎是中枢神经系统的严重疾病,美国约有300万癫癎患者,我国约有900万癫癎患者,约30%癫癎患者虽经过系统正规的抗癫癎药物治疗,仍不能得到有效的控制,成为耐药性癫癎(intracta—bleepilepsy)。耐药性癫癎最常见的是颞叶癫癎(temporal lobe epilepsy,TLE)。颞叶耐药性癫癎中约有65%~70%存在一侧海马硬化,常被视为致癎灶。目前治疗多为选择性的手术切除致癎灶,能够有效地减轻癫癎的发作和降低癫癎的死亡率,
出处
《癫痫与神经电生理学杂志》
2013年第3期187-191,共5页
Journal of Epileptology and Electroneurophysiology(China)
参考文献47
-
1Sebe JY,Baraban SC. The promise of an interneuron-based celltherapy for epilepsy[J]. Der Neurobiol,71 : 107-117.
-
2Ding D,Hong Z, Wang WZ,et al. Assessing the disease burdendue to epilepsy by disability adjusted life year in rural china[J]. Epilepsia,2006,47:2032-2037.
-
3Ryvlin P. Beyond pharmacotherapy: Surgical management[J].Epilepsia*2003 ,44(Suppl)5 :23-28.
-
4Thompson K. Transplantation of gaba-producing cells for sei-zure control in models of temporal lobe epilepsy [J]. Neuro-therapeutics ,2009,6:284-294.
-
5Armstrong RJ,Svendsen CN. Neural stem cells;From cell biol-ogy to cell replacement[J], Cell Transplani* 2000,9 : 139-152.
-
6McKay R. Stem cells in the central nervous system[J], Sci-ence,1997 ,276:66-71.
-
7Masuda T, lsobe Y? Aihara N,et al. Increase in neurogenesisand neuroblast migration after a small intracerebral hemor-rhage in rats[J]. Neurosci Lett,2007,425 :114-119.
-
8Lee HJ, Kim KS, Kim EJ, et al. Brain transplantation of im-mortalized human neural stem cells promotes functional recov-ery in mouse intracerebral hemorrhage stroke model[J]. StemCells,2007,25:1204-1212.
-
9Chen j? Zacharek A, Zhang C,et al. Endothelial nitric oxidesynthase regulates brain-derived neurotrophic factor expressionand neurogenesis after stroke in mice[J]. J Neurosci,2005,25 :2366-2375.
-
10Ohab JJ,Fleming S?Blesch A,et al. A neurovascular niche forneurogenesis after stroke [ J], J Neurosci,2006,26: 13007-13016.
-
1曾元英.脑出血与高血压病关系的临床分析[J].苏州医学院学报,1999,19(8):930-930.
-
2章惠如.癫痫40例复发的诱因分析及预防措施[J].中国乡村医药,2011,18(8):26-26. 被引量:1
-
3章惠英,金娜,章雅青,谢青,袁莉,徐云,过筠,袁晓玲.运动想象疗法对脑卒中偏瘫患者平衡功能恢复的影响[J].上海交通大学学报(医学版),2013,33(5):538-542. 被引量:30
-
4周红.早期康复指导对脑卒中病人运动功能和生活能力的影响[J].河南实用神经疾病杂志,2002,5(5):27-28.
-
5张淑云,张通.不同病程脑出血患者运动功能的康复疗效[J].中国康复理论与实践,2003,9(4):246-248. 被引量:14
-
6乔来军,姜波,焦继锋.脑卒中患者系统步行训练230例观察[J].中国民康医学,2004,16(7):439-440.
-
7周一海.过分追求完美者易患强迫症[J].华人时刊,2012(12):86-86.
-
8王广新,杨作成.难治性癫痫的分子遗传学研究进展[J].中风与神经疾病杂志,2006,23(6):760-762.
-
9章惠英,卿阳洋,章雅青,王凯,何雯,袁晓玲,陈蓄.太极拳步法运动想象对脑卒中偏瘫患者步行能力的影响[J].上海交通大学学报(医学版),2014,34(9):1268-1271. 被引量:14
-
10蔡立新,李勇杰,吴逊.难治性癫疒间的早期判断[J].临床神经病学杂志,2007,20(3):232-233. 被引量:8