脂质体前体的制备及其在食品营养物中的应用

Preparation of Proliposome and Its Application in Food Nutrients

脂质体具有良好的生物相容性和可降解性,在药物和食品领域中有着广泛应用,但存在稳定性差的缺点。脂质体前体的制备可有效克服这一问题,同时在保持给药过程中微粒的完整性、提高营养物溶解性和生物利用度、促进营养物胃肠吸收、促进营养物膜渗透能力、药物动力学等方面也有巨大的潜力。本文介绍近年来脂质体前体的制备方法和特点以及其在食品营养物方面应用的进展,以期为脂质体前体的研究提供一定的参考。

Liposome has been widely investigated in the field of food nutrient and drug delivery due to its bioeompatible and biodegradable properties. However, liposome has a poor stability such as aggregation, and susceptibility to hydrolysis and oxidation. Production of proliposome can be effectively overcome this problem, while maintaining the integrity of the particles in the administration process, improving the solubility and bioavailability of nutrients, enhancing the gastrointestinal absorption of nutrients, increasing the permeability of nutrients to cytomembrane, and modifying the pharmacokinetics. This review mainly introduces the recent advances on the study of the preparation methods and characteristics of proliposome, and lists the petential applications of proliposome in food nutrients.