前列腺增生合并急性尿潴留时血清前列腺特异性抗原浓度变化

Change of serum prostate specific antigen concentration in benign prostatic hyperplasia patients with acute urinary retention

目的观察良性前列腺增生（BPH）患者并发急性尿潴留（AUR）时对血清前列腺特异性抗原（PSA）的影响。方法对63例BPH并发AUR患者在导尿前检测其血清PSA浓度，留置尿管3d后复查，并以同期需手术治疗的BPH患者52例术前血清PSA浓度为对照。结果AUR组和对照组的血清PSA浓度分别为（16．41±8．32）ug/L和（5．34±3．73）ug/L，两组间差异有统计学意义（P〈0．01）。AUR组3d后复查PSA浓度，如组（PSA4～10ug/L）下降至（5．06±1．91）ug/L，A3组（PSA〉10ug／L）下降至（10．41±5．26）ug/L，与导尿前比较，差异有统计学意义（P〈0．05）。结论AUR可使BPH患者血清PSA浓度显著升高，但尿潴留缓解3d后PSA浓度可明显下降。

Objective To study the effect of acute urinary retention （AUR） in patients with be- nign prostate hyperplasia （BPH） on the serum prostate specific antigen （PSA） concentration. Methods The serum PSA concentrations were measured in 63 cases of BPH with AUR immediately and 3 days after relief of urinary retention, and were compared with those of 52 cases of BPH without AUR at the same time before operations. Results The mean concentrations of serum PSA in AUR group and non-AUR group were （16.41±8.32） and （5.34±3.73） μg/L respectively （P〈0.01）. In A2 group （PSA 4-10 μg/L） the mean serum PSA concentration was declined to （5.06±1.91 ） μg/L, that in A3 group （ PSA 〉 10μg/L） declined to （10. 41±5.26 ）μg/L 3 days after relief of urinary retention; respectively （for A2 group, P 〈 0. 05, and for A3 group,P 〈 0. 01 ）. Conclusion AUR in patients with BPH could dramatically elevate serum PSA concentration, but serum PSA concentration is gradually decreased 3 days after relief of urinary retention.