窖蛋白-1和埃兹蛋白在乳腺癌组织中的表达及其与预后的关系

Expression of caveolin-1 and ezrin in breast carcinoma tissue and its correlation with prognosis

目的探讨窖蛋白-1（Caveolin．1）和埃兹蛋白（Ezrin）在乳腺癌组织中的表达及与乳腺癌患者预后的关系。方法采用免疫组织化学法检测85例乳腺癌患者手术切除的癌组织和癌旁组织中Caveolin-1和Ezrin的表达水平。结果Caveolin-1在乳腺癌组织中阳性表达率为57．65％，在癌旁组织中阳性表达率为92．94％，两者差异有统计学意义（P〈0．01），Caveolin-1表达水平与乳腺癌TNM分期、淋巴结转移有关（P〈0．05）；Ezrin在乳腺癌组织中阳性表达率为64．71％，在癌旁组织中阳性表达率为20．00％，两者差异有统计学意义（P〈0．01），Ezrin表达水平与乳腺癌肿瘤大小、TNM分期、淋巴结转移明显相关（P〈0．05）。结论Caveolin-1与Ezrin是反映乳腺癌生物学行为较好的指标。

Objective To study the expression of Caveolin-1 and Ezrin in breast carcinoma and its correlation with prognosis. Methods Caveolin-1 protein and Ezrin expression in 85 cases of human breast carcinoma tissues and non-cancerous adjacent breast tissues was examined by using envision immunohisto- chemical method. Results The expression rate of Caveolin-1 was 57. 65% in breast carcinoma tissues, and 92. 94% in non-cancerous adjacent breast tissues （P 〈 0. 01 ）. The expression rate of Ezrin was 64. 71% in breast carcinoma tissues, and 20.00% in non-cancerous adjacent breast tissues （P 〈 0. 01 ）. The expression of Caveolin-1 was related to TNM stage and lymph node metastasis （P 〈 0. 01 ）. There was a close correlation between the expression of Ezrin and tumor size, TNM stage and lymph node metastasis （P 〈 0.05 ）. Conclusion The Caveolin-1 and Ezrin are good markers that reflect the biological behaviors of breast carcinoma.