钙池操纵钙通道STIM1和ORAI1在ⅢA期非小细胞肺癌中的表达
摘要
目的:研究ⅢA期非小细胞肺癌(NSCLC)患者手术肿瘤组织中STIM1或ORAI1蛋白表达和生存预后的关系。方法:应用S-P免疫组化方法检测70例ⅢA期NSCLC患者手术肿瘤组织STIM1和ORAI1蛋白表达,统计学分析其与患者无疾病生存预后的关系。结果:男性NSCLC患者中,STIM1低表达者预后有好于高表达者的趋势(21个月vs 12个月,P=0.06)。鳞癌NSCLC患者中,STIM1低表达者预后有好于高表达者的趋势(33个月vs 9个月,P=0.07)。结论:在鳞癌和男性ⅢA期NSCLC患者中,STIM1低表达可能预示着患者有较好的无疾病生存预后。
出处
《实用医学杂志》
CAS
北大核心
2013年第11期1810-1812,共3页
The Journal of Practical Medicine
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