摘要
目的:研究13种太白楤木皂苷单体对α-葡糖苷酶和α-淀粉酶的抑制作用。方法:通过体外模型试验测定13种太白楤木皂苷单体对α-葡糖苷酶和α-淀粉酶的抑制率。结果:皂苷单体4、12对α-葡糖苷酶的抑制作用较强,其半数抑制浓度(IC50)分别为(0.83±0.05)、(1.07±0.04)μmol/L;皂苷单体12对α-淀粉酶的抑制作用较强,其IC50为(1.02±0.03)μmol/L。结论:皂苷单体4、12对α-葡糖苷酶,皂苷单体12对α-淀粉酶均具有较好的抑制作用,可为后期试验提供一定参考。
OBJECTIVE： To study the inhibitory effect of 13 kinds of saponin monomer isolated from Aralia taibaiensis on the activities of a-glucosidase and α-amylase, and to discuss its hypoglycemic mechanism. METHODS： The inhibitory effects of 13 kinds of saponins monomer against the activities of α-glucosidase and a-amylase were examined using in vitro models. RESULTS： Saponin monomer 4 and 12 showed strong inhibitory effect on a-glucosidase in the inhibitory test in vitro. IC50 values were（0.83 ± 0.05） μtmol/L and （1.07 ± 0.04） μtmol/L, respectively. Saponin 12 showed strong inhibitory effect on α-amylase with IC50 of （1.02 ± 0.03） μtmol/L. CONCLUSIONS： Saponin monomer 4 and monomer 12 show strong inhibitory effect on a-glucosidase, and inhibito-ry effect of saponin monomer 12 on α-amylase is the best in the all. The study can provide reference for further test.
出处
《中国药房》
CAS
CSCD
2013年第23期2119-2121,共3页
China Pharmacy
基金
国家自然科学基金资助项目(No.81001673)
陕西省"13115"科技创新工程重大科技专项资助项目(No.2010ZDKG-62)
陕西省自然科学基础研究计划资助项目(No.2010JQ4018)
