妊娠合并恶性肿瘤终止妊娠与预后的相关性研究

Study on Malignancy in Pregnancy Termination of Pregnancy and Prognosis

目的:探讨妊娠合并恶性肿瘤终止妊娠与预后的相关性。方法:采用回顾性资料分析方法,收集了南方医科大南方医院、深圳市第一人民医院和北大深圳医院3家三级甲等医院1992-01～2008-12收治的在妊娠期被诊断为合并了恶性肿瘤的病例34例。根据是否在孕期终止妊娠分为两组:终止妊娠组和继续妊娠组。通过对两组妊娠周数、孕次、产次、症状发生到诊断为恶性肿瘤的时间和生存率之间进行比较分析。结果:妊娠合并恶性肿瘤继续妊娠组五年生存率:38.89%,中位数生存时间为10个月;终止妊娠组五年生存率43.75%,中位数生存时间为24个月。将两组生存时间描绘出生存曲线,对生存中位数时间比较采用Log-Rank检验:χ2=0.596,P=0.440,两组生存时间差异无统计学意义。结论:妊娠合并恶性肿瘤死亡率高,但孕期终止妊娠并不能延长患者生存时间。

Objective： To discuss the Malignancy in pregnancy termination of pregnancy and prognosis. Methods： The use of retrospective data analysis methodsm for the collection of the South Great Southern medical hospital, the First People＇s Hospital of Shenzhen, Shenzhen Hospital of Beijing University,three three -level hospital in January 1992 to December 2008 treated at the pregnancy was diagnosed as combined the 34 cases of malignant tumor cases. According to whether terminate gestation, the patients were divided into two groups： termination group and continue group. And we analysed the time and tivability from beginning symptom to malignant tumor for both two groups. Results：Malignancy in pregnancy to continue the five - year survival rate of pregnancy group 38. 89% ,meso - life span is 10 weeks; termination of pregnancy group of five -year survival rate of 43.75% ,meso - life span is 24 weeks. Will depict the survival time of two survival curves, survival curves for survival analysis of the Log - Rank test ： χ^2 = 0. 596, P = 0. 440, there is no significant difference in survival time between the two groups. Conclusions：Termination of pregnancy and during pregnancy should not extend the survival time of patients.