摘要
目的：建立消瘤胶囊中阿魏酸的含量测定方法。方法：采用Diamonsil C18柱（250mm×4．6mm，5prn）为填充柱，以乙腈-0．1％磷酸溶液（17：83）为流动相，检测波长为316am，流速为lmL／min，柱温为35℃进行检测。结果：阿魏酸质量浓度在1．112～111．2pg／mL范围内呈良好的线性关系（r=1．0），平均回收率为101．99％，RSD为1．48％，3批消瘤胶囊供试品中阿魏酸含量分别为0．26mg／g，0．31mg／g和0．44mg／g。结论：本法操作简便、快速、准确、精密度高、重复性好，适用于消瘤胶囊中阿魏酸的定量测定。
Objective： To establish a method for determining the content of Ferulic acid in Xiaoliu capsule. Methods： The separation was performed on Diamonsil C18 column（250 mm×4.6 mm, 5 μm） column with a rate of 1.0 mL/min. The mobile phase was composed of acetonitrile and 0.1% Phosphoric acid solution （17：83） at 35℃.The detection wave length was set at 316 nm. Results： There was a good linearity between the range of the concentration of 1.112 μg/ mL and 111.2μg/mL （r= 1.0）. The average recovery rate was 101.99%, and RSD was 1.48%. The Ferulic acid content in tile 3 batch Of Xiaoliu capsule is 0.26 mg/g, 0.31 mg/g and 0.44 mg/g, separately. Conclusion： This method is simple, rapid, accurate, of high-precision, and repeatable. It is suitable for the determination of Ferulic acid in Xiaoliu capsule.
出处
《抗感染药学》
2013年第2期118-120,124,共4页
Anti-infection Pharmacy
