浓缩当归分散片的制备及其溶出度测定

Study on Preparaion of Nongsuo Danggui Dispersible Tablets and Determination of Its Dissolution

目的:制备浓缩当归分散片并建立采用高效液相色谱法测定其溶出度的方法。方法:采用高效液相色谱法测定浓缩当归分散片中阿魏酸的溶出度。结果:阿魏酸在0.0557～0.557μg(r=0.9998)范围内与峰面积有良好的线性关系,平均加样回收率符合要求。采用pH6.8磷酸盐溶液为浓缩当归分散片溶出度的测定介质。结论:浓缩当归分散片溶出度测定方法简便、准确、专属性强,可用于该制剂的质量控制。

Objective： To prepare nongsuo danggui dispersible tablets and determine its dissolution.Methods： The dissolution of the tablets was determined by HPLC.Results： The linear range of ferulic acid was 0.0557 ～ 0.557 μg（r=0.9998）.The average recoveries met the requirement.Phosphate solution of pH 6.8 was the dissolution medium.Conclusion： The method is simple,accurate and has stronge specificity and can be used for the quality control of nongsuo danggui dissolveing tablets.