改进小量青霉素递增法预防妊娠梅毒吉海反应

Prevention of Jarisch-Herxheimer reaction in women of pregnant syphilis by using modified progressively increasing low-dose penicillin

目的观察改进小量青霉素递增法预防妊娠梅毒吉海反应发生的效果。方法将200例早期梅毒或TRUST滴度≥1:8的隐性梅毒孕妇分成2组进行预防性治疗并观察有无吉海反应的发生。结果 200例孕妇均完成了治疗,治疗组100例孕妇采用改进小量青霉素递增治疗,9例发生吉海反应,发生率为9%;对照组100例孕妇采用小量青霉素递增治疗,8例发生吉海应,发生率为8%;总共17例发生吉海反应,总发生率为8.5%(P>0.05)。结论两种方法在预防吉海反应的效果上差异无统计学意义,但改进小量青霉素递增法更实用。

Objective To observe the effect of modified progressively increasing low-dose penicillin in prevention of Jarisch-Herxheimer reaction in women of pregnant syphilis.Methods Two hundred pregnant syphilis cases inclduingf early syphilis or latent syphilis were divided into 2 groups randomly and the effect in prevention of Jariseh-Herxheimer reaction was observed.Results The 100 cases in treatment group were treated with modified increasing progressively low-dose penicillin and Jarisch-Herxheimer reaction occurred to 9 cases with an incidence of 9%.While another 100 cases in the control group were treated with progressively increasing low-dose of penicillin and Jarisch-Herxheimer reaction occurred to 8 cases with an incidence of 8%.The general incidence rate of Jarisch-Herxheimer reaction was 8.5%.Conclusions No significant differences of in incidence rate of Jarisch-Herxheimer reaction were observed between 2 groups,but the method of treatment group was more practical.