不同时期溃疡病检出率与幽门螺杆菌感染率的对照研究

The Study of the Detection Rate about Ulcer Disease and Helicobacter Pylori Infection in Different Times

目的:为了解HP根除治疗前后不同时期对胃镜下胃溃疡、十二指肠溃疡检出率的影响,探讨疾病的变化趋势。方法:以天津南开医院内科胃镜室为调查对象, 按照不同阶段分为三个组:1983～1986年为HP广泛根除前期组,1993～2009年为广泛根除组,2010～2012年为现阶段组。比较三个组的胃及十二指肠溃疡检出率,并对广泛根除组及现阶段组胃及十二指肠溃疡的HP感染率进行比较。结果: 广泛根除组与HP广泛根除前期组比较,GU及DU检出率均无统计学差异 (χ2=3.57,P>0.05;χ2=0.00015,P>0.05);现阶段组与广泛根除组比较,GU及DU的检出率均明显降低(χ2=92.84,P<0.01;χ2=75.55,P<0.01),HP感染率也明显降低(χ2=38.776,P<0.01;χ2=188.084,P<0.01)。结论:HP根除治疗有效降低了现阶段溃疡病的患病率,但非HP溃疡的增加为溃疡病远期发病率带来不确定性。非HP溃疡的病因学调查将成为今后溃疡调查与防治工作的重点。

Objective： To understand the incidence of ulcers at different stages before and after HP eradication therapy. Methods： The clinical data from Tianjin nankai hospital endoscopy room. The patients were divited into three groups： from 1983 to 1986 period for the former HP eradication group, from 1993 to 2009 period for the eradication group, from 2010 to 2012 period for the currently group.Their detection rates of gastric ulcer and duodenal ulcer were compared, and the HP infection rates were compared between eradicating group and currently group. Results： The detection rates of GU and DU were no significant change between former HP and eradication groups （χ ^2 =3.57 ,P0.05;χ 2 =0.00015 ,P0.05）, while they were significant decreased in currently group compared with eradication group（χ ^2 = 92.84,P0.01;χ ^2 =75.55,P0.01）,as so as their HP infection rates （χ ^2 =38.776,P0.01;χ ^2 =188.084,P0.01）.Conclusion： The current incidence is decreased by eradicating HP,but the long-term incidence is uncertainty because of the increasing of non-Hp ulcers.The cause of non-HP ulcers will become the focus in the future.