肝窦内皮细胞的研究进展

Research Progression of Hepatic Sinusoidal Endothelial Cell

目的分析并总结肝窦内皮细胞的表型标志以及其在肝脏疾病发生、发展过程中的作用的研究进展情况。方法以"肝窦内皮细胞"、"肝再生"及"肝脏疾病"作为关键词,利用PubMed、万方、CNKI等数据库检索近年来关于肝窦内皮细胞与肝脏疾病研究的相关文献并进行综述。结果肝窦内皮细胞具有特殊的细胞结构及表型标志,在肝脏再生、肝脏免疫耐受、肝脏纤维化及肝脏损伤的过程中最先感受"损伤信息",并且作为第一道屏障既起着保护肝脏的作用,同时也是肝脏损伤的最初改变,在肝脏疾病发生、发展的过程中起着重要的作用。结论肝窦内皮细胞功能复杂,其在肝脏疾病病变过程中具体如何发挥作用及发挥作用的机制尚不明确,有待进一步研究。

Objective To analyze and summarize the research progression of phenotypic markers of hepatic sinusoidal endothelial cell（HSEC）and its role in the development and progression of the liver diseases.Methods Databases such as PubMed,Wanfang,CNKI,etc were retrieved for the latest articles on research advance in HSEC using＂hepatic sinus endothelial cell＂,＂liver regeneration＂,and＂liver disease＂as key words.All of the publications about studies on relation between HSEC and liver disease were reviewed and summarized.Results HSEC with specific cytoarchitectures and phenotypic markers was initially received＂the message of damage＂in the process of liver regeneration,hepatic immunological tolerance,hepatic fibrosis,and liver damage.Additionally,HSEC as the first barrier not only enabled liver to be protected but also was regarded as the first alternation of liver damage.Therefore,HSEC played a great important role in the process of the onset and progression of the liver disease.Conclusions The function of HSEC is complex.How do play a role and its the mechanism is unclarified,it is needed to be further studied.