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新型胶原样凝集素的研究进展

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摘要 胶原样凝集素作为脊椎动物C-型凝集素超家族内的成员,以含有胶原样结构域及糖识别结构域为其显著特征。胶原样凝集素除了"经典"成员甘露聚糖结合凝集素(MBL)、表面活性蛋白A(SP-A)和SP-D外,还发现肝胶原样凝集素1(CL-L1)、肾胶原样凝集素1(CL-K1)和胎盘胶原样凝集素1(CL-P1)。在机体固有免疫系统中,这些"新"型胶原样凝集素除了同"经典"胶原样凝集素一样发挥着十分重要的作用外,它们还具有其独特的生理功能。本文综述了这些新发现的胶原样凝集素的分子结构、组织分布以及生物学功能等方面的研究进展。
作者 明亮 王万海
机构地区 郑州大学第一附属医院检验科
出处 《细胞与分子免疫学杂志》 CAS CSCD 北大核心 2013年第5期546-548,共3页 Chinese Journal of Cellular and Molecular Immunology
基金 河南省科技厅中外合作项目(114300510008)
关键词 胶原样凝集素 人肝胶原样凝集素1 人肾胶原样凝集素1 人胎盘胶原样凝集素1
分类号 R392.11 [医药卫生—免疫学] R977.6 [医药卫生—药品]
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参考文献16

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二级参考文献34

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细胞与分子免疫学杂志
2013年 第5期

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