胰岛素样生长因子2mRNA结合蛋白3在肺鳞癌的表达及预后分析

Expression of insulin-like growth factor 2 mRNA-binding protein 3 expression and analysis of prognosis in the patients with lung squamous cell carcinoma

目的探讨胰岛素样生长因子2 mRNA结合蛋白3(IMP3)在肺鳞癌中的表达及评价预后的意义。方法应用免疫组化染色,检测92例肺鳞癌及癌旁组织中IMP3蛋白的表达,结合临床病理学指标及总生存期进行统计学分析。结果肺鳞癌组织中IMP3阳性表达率明显高于癌旁正常组织(χ2=70.145,P<0.01),IMP3蛋白在肺鳞癌中的表达与组织分化程度低、有转移以及病理分期高密切相关(χ2分别为9.811、11.926和7.136,P<0.01);癌组织中IMP3蛋白的表达与患者术后总生存期呈负相关(Log-rank=23.889,P<0.01),IMP3阳性表达是预后的独立风险因素(风险比:0.436,95%置信区间:0.247～0.768,P<0.01)。结论 IMP3表达的肺鳞癌预后较差,可作为新的肺鳞癌标记物。

Objective To detect the expression of insulin-like growth factor 2 mRNA-binding protein 3 （ IMP3 ） in lung squamous cell carcinoma and explore its prognostic significance. Methods Tissue microarray of 92 patients with lung squa- mous cell carcinoma were examined for the expression of IMP3 by SP immunohistochemistry. Additionally, the correlation between IMP3 expression and the clinicopathological features of lung squamous cell carcinoma, and the relationship between prognostic factors and overall survival rate were analyzed by statistical methods. Results IMP3 expression rate in lung squa- mous cell carcinoma was significant higher than that in the adjacent lung tissues （X2 = 70.145, P 〈 0.01 ）. IMP3 expression was closely correlated with the poor differentiation （X2 =9.811, P 〈 0.01 ）, metastasis （X2 -- 11. 926, P 〈 0.01 ）, and higher pathologic stage （X2 = 7. 136, P 〈 0.01 ）. Importantly, it was negatively correlated with the overall survival rate （ Log-rank -- 23. 889, P 〈 0.01 ） ; After the operation, IMP3 emerged as a significantly independent hazard factor for the prognosis in lung squamous cell carcinoma （hazard ratio： 0. 436, 95%C1：0.247 -0.768, P 〈 0.01 ）. Conclusion IMP3 expression predicts a poor prognosis in the patients with lung squamous cell carcinoma, so it can be used as a novel lung carcinoma biomarker.