原发性肝癌癌旁组织胸腺嘧啶核苷磷酸化酶表达与微血管密度的关系

Relationship between thymidine nucleoside phosphorylase expression and microvascular density in para-carcinoma tissue of primary liver cancer.

目的探讨原发性肝癌癌旁组织胸腺嘧啶核苷磷酸化酶(TP)与微血管密度(MVD)的关系。方法选取海南医学院附属医院普外科切除的肝癌标本40例,采用免疫组织化学方法检测原发性肝癌癌旁组织蜡块中的TP和MVD的表达水平,并在高倍镜下计数微血管数。结果 TP阳性原发性肝癌癌旁组织的MVD明显高于TP阴性原发性肝癌癌旁组织。结论原发性肝癌癌旁组织中TP具有促进组织中血管增生作用,TP阳性原发性肝癌患者术后可选用卡培他滨化疗。

Objective To study the relationship between thymidine nucleoside （TP） phosphorylase expres- sion and microvascular density （MVD） in paracarcinoma tissue of primary fiver cancer. Methods Forty samples of liver cancer from Department of General Surgery in the Affiliated Hospital of Hainan Medical University were collected, lmmunohistochemical method was applied to detect the expression levels of TP and microvascular density in para-carcinoma tis-sue of primary liver cancer. The number of microvessels was observed at high magnification. Results The MVD levels in para-carcinoma tissue of primary liver cancer with positive TP was obviously higher than that with negative TP. Conclusion TP can promote vascular hyperplasia role in para-carcinoma tissue of primary liver cancer, TP positive patients with primary liver cancer can choose capecitabine chemotherapy after surgery.