213例胎膜早破者胎盘病理改变与妊娠结局的关系探讨

Correlation analysis between placental pathology and pregnancy outcomes in 213 cases of premature rupture of membranes.

目的分析胎膜早破者胎盘病理改变情况,探讨其与妊娠结局之间的关系。方法在我院入住孕妇中选取213例胎膜早破者作为观察组,同时选取无胎膜早破的正常孕妇200例为对照组。采用常规HE染色对两组孕妇胎盘形态学进行观察,分析胎盘病理变化与妊娠结局的关系。结果两组中胎盘病理改变包括胎盘胎膜感染、合体细胞结节增多、间质血管增多、纤维化蛋白沉积、胎盘钙化等。其中观察组中各病理变化的发生所占比例与对照组比较明显升高,差异均具有统计学意义(P<0.05);对照组中新生儿感染、产褥感染、胎儿窘迫等妊娠结局的发生率明显低于观察组,差异具有统计学意义(P<0.05),对照组中新生儿窒息的发生率与观察组比较差异无统计学意义(P>0.05)。结论胎膜早破者胎盘病理改变与妊娠结局有密切关系,通过对胎盘病理改变的监测,对防治不良妊娠结局具有重要的指导意义。

Objective To analyze the placental pathology in patients with premature rupture of membranes （PROM）, and to explore the relationship between placental pathology and pregnancy outcomes. Methods Two hundred and thirteen pregnant women with PROM in our hospital were selected as the observation group, and 200 normal pregnant women at the same time were enrolled as the control group. The placenta morphology were observed using conventional HE staining. The pathological changes of the placenta, and its relationship with pregnancy outcome were analyzed. Results Placental pathology in the two groups included infection of placental membranes, fibrosis protein deposition, increased syncytial nodules, increased stromal vascular placental calcification. The occurrence of pathological changes in the observation group was significantly higher, compared with the control group （P〈0.05）. The incidence of pregnancy outcomes of neonatal infection, puerperal infection and fetal distress in the control group was significantly lower than those in the observation group （P〈0.05）. The incidence of neonatal asphyxia showed no statistic.ally significant difference between the two groups （P〉0.05）. Conclusion Placental pathology in premature rupture of membranes is closely related to pregnancy outcomes, which has a certain guiding significance through the placental pathology monitoring in the prevention and treatment of adverse pregnancy outcomes.