期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

RANTES基因多态性表达与肺结核的相关性研究进展 被引量：1

下载PDF
导出
摘要 为探讨RANTES基因多态性与肺结核遗传易感性的关系,采用PCR技术检测肺结核患者组和正常对照组的RANTES基因启动子-403G/A和-28C/G与内含子In1.1T/C位点的基因型,分析其多态性的表达。此研究对阐明肺结核发生的分子机制、评估其发生、发展及预后以及在预防和治疗中建立基于免疫和遗传学的个体化方案具有重要意义。本文就近年来RANTES基因多态性的表达与肺结核的相关性研究进展做一综述。
作者 詹前美 胡宏波
机构地区 柳州市柳铁中心医院 南方医科大学附属柳州医院检验科
出处 《海南医学》 CAS 2013年第11期1648-1649,共2页 Hainan Medical Journal
基金 广西壮族自治区卫生厅科研基金(编号:Z2012551)
关键词 RANTES基因 多态性表达 肺结核 相关性 进展
分类号 R521 [医药卫生—内科学]
  • 相关文献

参考文献12

  • 1I Rothschild BM, Martin LD, Lev G, et al. Mycobacterium tubereulo- sis complex DNA from an extinct bison dated 17,000 years before the present [.1]. Clin Infect Dis, 2001, 33(3): 305-311.
  • 2World Health Organization. Global Tuberculosis Report. Geneva: WHO, 2009.
  • 3Appay V, Rowland-Jones SL. RANTES: a versatile and controver- sial chemokine [J]. Trends Immunol, 2001, 22(2): 83-87.
  • 4Murooka "IT, Wong MM, Rahbar IL t al. CCLS--CCRS--mexliatod apoptosis in T cells: Requirement for glyc.osaminoglycan binding and CCL5 aggregation [J]. J Biol Chcm, 2006, 281(35): 25184-25194.
  • 5Vesosky B, Rotfinghaus EK, Stromberg P, et al. CCL5 participates in early protection against Mycobacterium tuberculosis [J]. J Leu- koc Biol, 2010, 87(6): 1153-1165.
  • 6M'ndez-Samperio P. Expression and regulation of chemokines in mycobacteriai infection [J]. J Infect, 2008, 57(5): 374-384.
  • 7Sadek MI, Sada E, Toossi Z, et al. Chemokines induced by infection of mononuclear phagocytes with mycobacteria and present in lung alveoli during active pulmonary tuberculosis [I]. Am J Respir Cell Mol Biol, 1998, 19(3): 513-521.
  • 8Abhimanyu, Mangangcha IR, Jha P, et al. Differential serum cyto- kine levels are associated with eytokine gene polymorphisms in north Indians with active pulmonag tuberculosis [J]. Infect Genet Evol, 2011, 11(5): 1015-1022.
  • 9Snchcz-Castati6n M, Baquero IC, SInchez-Velasco P, ctal. Poly- morphisms in CCL5 promoter arc associated with pulmonary tuber- culosis in northern Spain [.1]. Int .l Tubcrc Lung Dis, 2009, 13(4): 480--485.
  • 10Chu SF, Tam CM, Wong HS, et al. Association betwocn RANTES functional polymorphisms and tuberculosis/n Hong Koag Chinos [J]. Genes Immun, 2007, 8(6): 475-479.

同被引文献29

  • 1高贵民,吴健民（审校者）.嗜酸性粒细胞活化趋化因子与支气管哮喘的研究进展[J].国际免疫学杂志,2006,29(2):93-96. 被引量：12
  • 2World Health Organization. Global tuberculosis report 2013 [ R ]. Geneva : WHO,2013.
  • 3徐勤,张以勤.趋化因子RANTES在动脉粥样硬化疾病中的作用[J].中外健康文摘,2011,8(47):444-446.
  • 4DORNER BG, SCHEFFOLD A, ROLPH MS, et al. MIP-lalpha, MIP-lbeta, RANTES, and ATAC/ lymphotactin function together with IFN-gamma as type 1 cytokines[ J]. Proc Natl Acad Sci USA,2002, 99(9) :6181-6186.
  • 5FERREIRA MA. Cytokine expression in allergic inflammation: systematic review of in vivo challenge studies [ J ]. Mediators Inflamm, 2003,12 (5) : 259- 267.
  • 6VIELHAUER V, BERNING E, EIS V, et al. CCR1 blockade reduces interstitial inflammation and fibrosis in mice with glomerulosclerosis and nephrotic syndrome [ J ]. Kidney Int, 2004,66 ( 6 ) : 2264-2278.
  • 7POKKALI S, DAS SD. Augmented chemokine levels and chemokine receptor expression on immune cells during pulmonary tuberculosis [ J ]. Hum Immunol, 2009, 70(20) :110-115.
  • 8SELVARAJ P, HARISHANKAR M, SINGH B, et al. Effect of vitamin D3 on chemokine expression in pulmonary tuberculosis [ J ]. Cytokine, 2012,60 ( 1 ) : 212-219.
  • 9VESOSKY B, ROTI'INGHAUS E K, STROMBERGP, et al. CCI-5 participates in early protection against Mycobacterium tuberculosis [ J ]. J Leukoc Bio1,2010, 87(6) :1153-1165.
  • 10MINDEZ-SAMPERIO P. Expression and regulation of ehemokines in myeobacterial infection [ J ]. J Infect,2008,57 ( 5 ) : 374-384.

引证文献1

二级引证文献2

海南医学
2013年 第11期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部