摘要
目的 应用失血、内毒素双重因素制作大鼠MODS模型 ,并对胃肠道激素的变化作了研究。方法 大鼠动脉放血及腹腔注射内毒素制作MODS模型 ,并进行胃肠道病理形态学观察 ,胃液 pH及血浆胃泌素 (GAS)和胃动素 (MTL)检测。结果 MODS大鼠胃肠道粘膜屏障受损 ;胃液 pH值下降 ;血浆GAS、MTL水平升高。 结论 胃肠激素水平的变化可能是影响MODS机体胃肠道及全身疾病发生。
? Objective To study the changes of gastric hormones in multiple organ dysfunction syndrome (MODS) rats.Methods The MODS rat models were made of hemorrhage and endotoxin,and changes of the gastrointestinal pathology,the gastric juice pH,the plasma gastrin and the motilin were also studied.Results The gastric mucosa was impaired,the gastric juice pH was dropped,the plasma gastrin and the motilin were hoisted,respectively.Conclusion It is proposed that the gastric hormones play an important role in the gastrointestinal injury in MODS. 〔
出处
《创伤外科杂志》
2000年第2期86-88,共3页
Journal of Traumatic Surgery
关键词
多器官功能障碍
失血
内毒素
胃泌素
胃动素
Multiple organ dysfunction syndrome(MODS)
Hemorrhage
Endotoxin
Gastrin
Motilin
