IVF短时受精补ICSI与其它受精方式临床结局的比较

Comparison of Clinical Outcome of IVF Short-time Insemination and Immediate Rescue ICSI vs Other Insemination Methods

【目的】比较短时受精补卵细胞胞质内单精子注射（ICSI）与短时受精、ICSI周期的临床应用结局。【方法】收集体外受精-胚胎移植（IVF-ET）的患者6897例，IVF短时周期4060例（A组），IVF短时补ICSI周期1177例（B组），ICSI周期1660例（c组），比较三组受精率、妊娠率及流产率。【结果】A组、B组、C组正常受精率分别为74．07％、69．08％、83．16％，三组比较差异有统计学意义（Pd0．05）；A组、B组、c组临床妊娠率、流产率分别为44．8％、11．1％，43．0％、11．9％，43．9％、10．9％，三组临床妊娠率、流产率比较均无统计学差异（P〉O．05）。【结论】短时受精补ICSI组的正常受精率低于短时受精、ICSI周期组，但体外受精的临床临床妊娠率及流产率无统计学差异，故短时受精补ICSI是辅助生殖值得采用的受精方法。

[Objective] To compare the clinical application outcomes of short time insemination and imme- diate rescue intracytoplasm single spermatozoa injection （ICSI） vs short time insemination or ICSI cycle. [Methods] Totally 6897 patients with in vitro fertilization and embryo transfer（IVF-ET） were collected. Group A（ n =4060） received short term cycle. Group B（ n --1177） received rescue ICSI cycle. Group C（ n = 1660） received ICSI cycle. Fertilization rate, pregnancy rate and abortion rate among 3 groups were compared. [Results] Normal fertilization rate of group A, B and C were 74.07 %, 69.08 % and 83.16 % respectively, and there was significant difference among 3 groups. Clinical pregnancy rate of group A, B and C were 44.8~ 43.0~ and 43.90//00, respectively. Abortion rate of group A, B and C were 11.1~/00, 11.9% and 10. 90//00 re- spectively. There was no significant difference in clinical pregnancy rate and abortion rate among 3 groups（ P 〉0.05）. [Conclusion] Normal fertilization rate in short time insemination and immediate rescue ICSI group is lower than that in short time insemination and ICSI cycle group, but there is significant difference in clinical pregnancy rate and abortion group of in vitro fertilization. Therefore, short time insemination and immediate rescue ICSI is worthy of clinical application in assisted fertilization.