MR-1S在卵巢癌组织中的表达及意义

Expression of MR-1S in Ovarian Carcinoma and Its Significance

【目的】探讨s型人肌原纤维生成调节因子（MR-1S）在卵巢癌组织中的表达及意义。【方法】收集本院近三年手术治疗的120例卵巢癌患者组织（A组），同时选取60例卵巢良性肿瘤组织（B组）和50例卵巢正常组织（c组），采用荧光定量PCR法检测三组MR—ISmRNA的表达，分析其表达与其，临床分期和病理分级之间的相关性。【结果】A组、B组和C组中MR-1SmRNA表达量分别为（2．33±0．41）、（0．89±0．78）、（0．58±0．23），三组比较差异有统计学意义（P〈0．05）；A组中的MR-1SmRNA表达与患者的临床分期及病理分级间不相关（P〉0．05），但上皮性癌中浆液性癌组织中的MR-1SmRNA表达量显著高于粘液性癌和内膜性癌，其差异有统计学意义（P〈O．05）。【结论】MR_1s基因在卵巢癌组织中高表达，可成为卵巢癌诊断的一个新的标志物。

[Objective]To explore the expression of human short-type myfibrillogenesis regulator-I （MR- IS） in ovarian cancer and its significance. [Methods]The tissues ~＇rom 120 patients with ovarian cancer under- going surgical treatment in our hospital were collected in recent 3 years（group A）. At the same time, 60 cases of benign ovarian cancer tissues（group B） and 50 cases of normal ovarian tissues（group C） were collected. Fluorescence quantitative PCR method was used to detect the expression of MR-1S mRNA. The relationship of MR-1S mRNA expression with the clinical stage and pathologic grading was analyzed. [Results]The expres- sion levels of MR-1S mRNA in group A, group B and group C were （2.33＋0.41）, （0.89＋0.78） and （0.58 ＋0.23） respectively, and there was significant difference（ P d0.05）. MR-1S mRNA expression in group A was not associated with clinical stage and pathological grading. The expression levels of MR-1S mRNA in se- rous carcinoma of epidermal cancer were significantly higher than those in mucinous and endometrioid carcinoma, and there was significant difference（ P d0.05）. [Conclusion]MR-IS gene is highly expressed in ovarian cancer tissues, and it may be a new biomarker for the diagnosis of ovarian cancer.