美沙拉嗪治疗腹泻型肠易激综合征的疗效观察

Observation on the Efficacy of Mesalazine for the Treatment of Diarrhea-predominant Irritable Bowel Syndrome

【目的】观察美沙拉嗪治疗腹泻型肠易激综合征（IBS）的疗效。【方法】将本院40例IBS患者随机分为两组，每组各20例。治疗组给予美沙拉嗪0．5g 3次／日，口服；对照组给予匹维溴铵50mg，3次／天，口服。两组均连续治疗4周。观察比较两组患者治疗前后临床疗效、血清肿瘤坏死因子α（TNF-α）、白细胞介素-8（IL-8）含量的变化。【结果】治疗组总有效率为80．0％，明显高于对照组（65．0％），且两组相比较差异有显著性（P〈0．05）；经治疗后治疗组血清TNF-α、IL-8水平明显低于治疗前和对照组，且差异均有显著性（P〈0．05）。【结论】美沙拉嗪治疗腹泻型IBS效果较好，其作用机制可能与抑制TNF-α，IL-8等炎症因子有关。

[Objective]To observe the efficacy of mesalazine for the treatment of diarrhea-predominant irritable bowel syndrome（D-IBS）. [Methods] Forty IBS patients in our hospital were randomly divided into 2 groups with 20 cases in each groups. The treatment group was treated with oral mesalazine 0.5g 3 times a day, and the control group was given oral pinaverium bromide 50mg 3 times a day. The two groups were treated continuously for 4 weeks. Clini- cal efficacy was observed before and after treatment. Serum tumor necrosis factor-alpha（TNF a） and interleukiw8 （IL-8） were measured and compared before and after treatment. [Results] The total effective rate of treatment group was 80%, which was obviously higher than that of control group（65%）, and there was significant difference. Serum levels of TNF-α and IL-8 in treatment group after treatment were obviously lower than those in control group and hefore treatment, and there was significant difference（ P 〈0.05）. [Conclusion] Mesalazine for the treatment of diarrhe-α-predominant irritable bowel syndrome has good effect. Its mechanism may be related to the inhibition of TNF-α, IL-8 and other inflammatory factors.