维吾尔族173例与汉族163例体检者肺毛细血管膜弥散和肺毛细血管血量与肺一氧化碳弥散量差异性分析

Study of the difference in pulmonary membrane diffusing, pulmonary capillary blood volume and diffusion capacity for carbon monoxide between Uygur nationality and Han nationality in Xinjiang

目的比较在我院体检的维吾尔族和汉族肺通气功能、弥散功能正常值、肺毛细血管血量（VC）与肺一氧化碳弥散量（DLCO）之间的差异。方法对在我院体检的336例（汉族163例，维吾尔族173例）成人进行回顾性分析，常规进行肺功能及弥散功能检查，包括第1秒用力呼气容积（FEV1）、第1秒用力呼气容积／用力肺活量（FEV1／FVC）、DLCO、单位肺泡弥散量（KCO）、肺泡毛细血管膜弥散量（Dm）及Vc。通过年龄分层比较，对年龄、身高、体重等因素进行相关分析。结果维吾尔族组和汉族组肺通气功能呼气峰流量（PEF）比较差异有统计学意义[（7．2±2．0）L／s比（6．8±2．0）lMs]（P〈0．05），弥散功能DLCO、Vc、KCO比较差异有统计学意义[（8．0±2．0）mmol／（min·kPa）比（8．5±1．8）mmol／（min·kPa），（70±19）ml（77±20）ml，（1．59±0．20）mmol／（min·kPa·L）比（1．73±0．25）mmol／（min·kPa·L）]（P〈0．01）；通过维吾尔族和汉族年龄分层进行比较，最大呼气中期流速（MMEF25％～75％）、DLCO、KCO、Dm均在40岁以后与30～39岁组间比较呈下降趋势，差异有统计学意义（P（0．05），Vcmax、FEV1、Vc则在50岁以后与30～39岁组间比较，差异有统计学意义（P〈0．05）。结论我院体检的维吾尔族和汉族肺通气功能差异，主要表现在弥散功能方面的差异。民族间弥散值差异是否与少数民族居住的环境、生活饮食习惯等因素相关有待于进一步分析探讨。

Objective To compare the difference of pulmonary ventilation function, diffusion function value, pulmonary capillary blood volume （VC） and pulmonary diffusion capacity for carbon monoxide （DLCO） between Uygur and Han nationalities in the hospital. Methods All 336 cases of physical examination were analyzed retrospecively, routine pulmonary function and diffusing capacity were examined, including the forced expiratory volume in one second （ FEV1 ）, forced expiratory volume in the first second and forced vital capacity （ FEV1/FVC ）, DL- CO, unit of alveolar diffusing capacity （KCO）, the alveolar-capillary membrane diffusing （Dm） and Vc. Through the comparison of stratified for age, correlation analysis age, height, weight and other factors. Results Among the 336 cases, there was differences in PEF between Uygur nationality and Han nationality [ （ 7.2 ± 2. 0） L/s vs （ 6.8 ± 2. 0） L/s ] （ P 〈 0.05 ）, DLCO, Vc, KCO had significant difference [ （ 8.0 ± 2.0） mmol/（ min . kPa） vs （ 8.5 ±1.8）mmol/（min.kPa）, （70±19）ml vs （77 ±20）ml, （1.59 ±0.20）mmol/（min . kPa. L） vs （1.73 ± 0.25 ） mmol/（ min .kPa. L） ] （ P 〈 0.01 ） ; by age stratification for comparison, Vcmax, FEV1, Vc were decreased after the age of 50 years, the age difference was significant between the two groups （ P 〈 0.05 ） ; MMEF 25%-75%, DLCO, KCO, Dm were decreased after the age of 40 years, the age difference was significant between the two groups （ P 〈 0.05 ）. Conclusions Pulmonary ventilation function does not show difference between nationalities ; the main difference is the diffusion function. Whether national dispersion value differences are related with Uygur overweight and obesity. Minority living environment, living habits and other factors need to be further discussed.