期刊文献+

拉莫三嗪在特殊人群中的应用 被引量:3

The Application of Lamotrigine in Special Populations
原文传递
导出
摘要 拉莫三嗪是目前临床上普遍使用的一线抗癫药物,其药动学、治疗效果、耐受性等在不同人群中有所差别。本文主要总结拉莫三嗪在新生儿、婴儿、老年人及育龄期女性中的应用。 Lamotrigine is commonly prescribed as a first-line antiepileptic drug. Its pharmacokinetics, efficacy and tolerability, are diverse in different populations. The application of lamotrigine in newborns, infants, elders and women of child-bearing were summarized.
作者 顾婧 丁美萍
出处 《中国临床神经科学》 2013年第3期360-363,共4页 Chinese Journal of Clinical Neurosciences
基金 浙江省自然科学基金(编号:Y2080475)
关键词 癫痫 拉莫三嗪 药动学 疗效 不良反应 epilepsy lamotrigine pharmacokinetics treatment outcome adverse effect
  • 相关文献

参考文献23

  • 1Ohman I, Vitols S, Tomson T. Lamotrigine in pregnancy: pharma- cokinetics during delivery, in the neonate, and during lactation[J]. Epilepsia,2000,41:709-7 13.
  • 2Mikati MA, Fayad M, Koleilat M. Efficacy, tolerability, andkinetics of lamotrigine in infants[J]. J Pediatr,2002,141:31-35.
  • 3Pina-Garza JE, Levisohn P, Gucuyener K, et al. Adjunctive lamotrigine for partial seizures in patients aged 1 to 24 months[J]. Neurology,2008,70:2099-2108.
  • 4Pina-Garza JE, Elterman RD, Ayala R, et al. Long-term tolerabil- ity and efficacy of lamotrigine in infants 1 to 24 months old[J]. J Child Neurol,2008,23:853-861.
  • 5Messenheimer JA, Giorgi L, Risner ME, et al. The tolerability of lamotrigine in children[J]. Drug Saf,2000,22:303-312.
  • 6Arif I-l, Svoronos A, Resor SR Jr, et al. The effect of age and comedication on lamotrigine clearance, tolerability, and efficacy [J]. Epilepsia,2011,52:1905-1913.
  • 7Mauri Llerda JA, Tejero C, Mercade JM, et al. Lamotrigine and epilepsy in the elderly: observational study of low-dose monotherapy[J]. Int J Clin Pract,2005,59:651-654.
  • 8Punyawudho B, Ramsay RE, Macias FM, et al. Population pharma- cokinetics of lamotrigine in elderly patients[J]. J Clin Pharmacol, 2008,48:455-463.
  • 9Sidhu J, Job S, Singh S, et al. The pharmacokinetic and pharmaco- dynamic consequences of the co-administration of lamotrigine and a combined oral contraceptive in healthy female subjects[J]. Br J Clin Pharmacol,2006,61:191-199.
  • 10Sabers A, Ohman I, Christensen J, et al. Oral contraceptives reduce lamotrigine plasma levels[J]. Neurology,2003,61:570-571.

同被引文献26

  • 1张帆,朱毅平,周虎江.血清白蛋白含量与氯氮平血药浓度及副反应的相关性研究[J].浙江临床医学,2004,6(12):1048-1048. 被引量:2
  • 2黄春新,周广耀,韩方璇.游离丙戊酸血清药物浓度的测定[J].中国药学杂志,2005,40(11):855-857. 被引量:6
  • 3Tomson T, Ohman I, Vitols S. Lamotrigine in pregnancy and lacta- tion: a case report[J]. Epilepsia, 1997,38:1039 -1041.
  • 4Newport D J, Pennell PB, Calamaras M R, et al. Lamotrigine in breast milk and nursing infants:determination of expasure[J]. Pedi- atr/cs, 2008,122 : e223 - e231.
  • 5Lee W, Kim JH, Kim HS, et al. Determination of lamotrigine in hu- man serum by high - performance liquid chromatography - tandem mass spectrometry[ J]. Neurol Sci, 2010,31:717-720.
  • 6Forssblad E, Efiksson AS, Beck O. Liquid chromatographic deter- mination of plasma lamotrigine in pediatric samples. [ J ]. J PharmBiomed Anal, 1996,14:755 - 758.
  • 7Pellock JM. The clinical efficacy of lamotrigine as an antiepileptic drug[ J ]. Neurology, 1994,44 ( Suppl. 8 ) :29 - 35.
  • 8Ohman I, Vitols S, Tomson T. Lamotrigine in pregnancy: pharma- cokinetics during delivery, in the neonate, and during lactation [ J ]. Epilepsia, 2000,41:709 - 713.
  • 9Ohman I, Luef G, Tomson T. Effects of pregnancy and contraception on lamotrigine disposition : new insights through analysis of lamotrigi- ne metabolites[ J]. Seizure, 2008,17 : 199 - 202.
  • 10Maheshwari A, Athale S, Lekhra OP. Comparative safety of antiepileptic drugs during pregnancy[J]. Neurology, 2013, 80 (7) : 689.

引证文献3

二级引证文献14

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部