常见镰刀菌素与细胞凋亡的研究进展

Recent progress in the study of common fusarium mycotoxins on apoptosis of cells

某些常见镰刀菌素如伏马菌素 B1 、T- 2毒素、脱氧雪腐镰刀菌烯醇、镰刀菌烯酮 - X可以诱导多种细胞发生凋亡 ,如肝细胞、肾细胞、胃肠细胞、免疫细胞和传代细胞。这些镰刀菌素诱导细胞凋亡的机制较为复杂 ,可能与神经鞘氨醇、某些基因如 P2 1、蛋白激酶、CAMP信号系统、细胞内 Ca2 + 水平等许多因素有关。

Fumonisin B 1, T\|2 toxin, Fusarenon\|X and Deoxynivalenol, which are all mycotoxins produced by fusarium , could induce apoptosis of liver cell, kidney cell, gastrointestinal epithelial cell, immunological cells as well as several cell lines of human and animals. The possible mechanisms of apopotosis induction are complicated. Sphingol,p21 gene, protein kinase, CAMP signal system and intracellular Ca 2+ level, might be involved in the cellular apoptosis induction by Fusarium mycotoxins.