IKKi在肝硬化相关肝细胞癌中的表达

Expression of IKKi in cirrhosisrelated hepatocellular carcinoma

目的:研究核因子κB(nuclear factorκB,NF-κB)信号通路中IKKi蛋白在肝硬化相关肝细胞癌(hepatocellular carcinoma,HCC)中的表达水平及其临床病理意义.方法:采用免疫组织化学方法检测66例肝硬化相关HCC IKKi蛋白表达,同一病例癌旁肝硬化组织作为对照,收集患者临床病理资料,分析HCC IKKi蛋白表达水平以及与临床病理参数的关系.结果:(1)IKKi在HCC与癌旁肝硬化组织表达水平有明显差异性(P=0.016),IKKi在癌周肝硬化组织表达强度明显强于HCC;(2)IKKi在HCC中的表达水平与肿瘤分化程度呈正相关,即IKKi表达水平越低,HCC分化程度越低(P=0.019,r=0.278);与肿瘤直径呈负相关,即IKKi表达水平越低,肿瘤体积越大(P=0.011,r=-0.311);(3)IKKi在HCC中的表达水平与年龄(P=0.034,r=0.261)、Child-Pugh分级(P=0.046,r=0.246)、乙型肝炎家族史(P=0.017,r=0.292)呈正相关.结论:IKKi在HCC表达下调提示IKKi在乙型肝炎病毒感染-病毒性肝炎-肝硬化-HCC的发生中可能起抑制肿瘤形成的作用.

AIM： To assess the clinical significance of IKKi protein expression in cirrhosis-related hepatocel- lular carcinoma （HCC）. METHODS： Immunohistochemistry was used to detect IKKi expression in 66 cirrhosis-related HCC specimens and matched tumor-adjacent cirrhosis specimens. The association of IKKi ex- pression with clinical and pathological featuresof HCC was analyzed RESULTS： IKKi expression level was signifi- cantly higher in cirrhosis-related HCC than in tumor-adjacent cirrhosis tissue （P = 0.016）. IKKi expression in HCC was positively correlated with tumor differentiation （P = 0.019, r = 0.278）, age （P = 0.034, r = 0.261）, Child - Pugh classifica- tion （P = 0.046, r =0.246） and family history of hepatitis B （P = 0.017, r = 0.292）, but was negatively correlated with tumor size （P = 0.011, r = -0.311）. CONCLUSION： Low expression of IKKi in HCC implies that IKKi may prevent the evolution of hepatitis B virus infection-viral hepatitis-cirrho- sis-HCC.