肠道丝氨酸蛋白酶与腹泻型肠易激综合征

Gut Serine Proteases and Diarrhea-predominant Irritable Bowel Syndrome

肠易激综合征(IBS)为临床常见功能性肠病,其病理生理学机制迄今尚未完全阐明。近年研究发现腹泻型IBS(IBS-D)患者肠黏膜和肠腔内丝氨酸蛋白酶的表达水平和活性明显增高,丝氨酸蛋白酶可能通过激活蛋白酶激活受体-2(PAR-2)引起肠黏膜通透性增加和内脏敏感性增高,在IBS-D的发病中起重要作用。本文就肠道丝氨酸蛋白酶与IBS-D的研究进展作一综述。

Irritable bowel syndrome （IBS） is a commonly seen functional bowel disorder in clinical practice, however, its pathophysiological mechanism is still not fully known. Recently, some studies showed that the expression level and activity of serine proteases were increased significantly in intestinal mucosa and lumen in patients with diarrhea-predominant IBS （IBS-D）. The elevated serine proteases triggered protease-activated receptor-2 （PAR-2）-mediated increase in colonic paracellular permeability and visceral sensitivity, which suggested a possible role of serine proteases in the pathogenesis of IBS-D. This article reviewed the progress in study on gut serine proteases and IBS-D.