结直肠癌肝转移围手术期的治疗进展

Research progress of perioperative therapy for liver metastases of colorectal cancer

手术切除是结直肠癌肝转移最主要和最有效的治疗手段,但如何应对术后较高的复发风险并进一步改善生存是临床上亟待解决的问题。近年来,术后全身化疗、术前化疗和围手术期化疗已经在相关研究中进行了探讨,以期降低相关的复发风险。同时随着新的药物和治疗手段的不断涌现,第3代化疗药物和最新的靶向治疗药物以及肝动脉灌注化疗等局部治疗也用于结直肠癌肝转移的临床研究,并取得了一定成果。本文就这方面的相关进展作一综述。

Surgical resection is the major and most effective therapeutic approach for colorectal cancer with liver metastasis, with a fairly high recurrence rate after operation. It needs to decrease the risk of recurrence and prolong the survival for these patients undergoing surgical removal of liver metastases. Recent years, pre-, post- and peri-operative chemotherapy have been introduced into some studies to solve the problem. Meanwhile, with the development of new agents and new local treatment means, some promising re- sults have been obtained in some studies. Focusing on the challenge, our paper reviews the latest progress of treatment available in clinical practice.