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索拉非尼联合立体定向放疗治疗晚期肾癌脑转移一例 被引量：3

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摘要 脑转移是严重威胁肾癌患者的一类临床事件，分子靶向药物的问世为移性肾癌的治疗带来了新的机遇，此类药物是否可用于肾癌脑转移的治疗、是否可以联合立体定向放疗来治疗肾癌脑转移值得我们关注。中国医学科学院肿瘤医院泌尿外科使用索拉非尼联合立体定向放疗成功治疗肾癌脑转移1例，观报道如下。
作者 毕新刚 马建辉
机构地区 中国医学科学院北京协和医学院肿瘤医院肿瘤研究所泌尿外科
出处 《中华医学杂志》 CAS CSCD 北大核心 2013年第20期1600-1600,共1页 National Medical Journal of China
关键词 立体定向放疗 晚期肾癌 索拉非尼 脑转移 治疗 分子靶向药物 医学科学院 临床事件
分类号 R737 [医药卫生—肿瘤]
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参考文献5

  • 1Cochran DC, Chan MD, Aklilu M, et al. The effect of targeted agents on outcomes in patients with brain metastases from renal cell carcinoma treated with Gamma Knife surgery. J Neurosurg, 2012,116:978-983.
  • 2Samlowski WE, Majer M, Boucher KM, et al. Muhidisciplinary treatment of brain metastases derived from clear cell renal cancer incorporating stereotaetic radiosurgery. Cancer, 2008,113 : 2539- 2548.
  • 3Walid MS, Johnston KW. Suceessful treatment of a brain- metastasized renal cell carcinoma. Ger Med Sci,2009,7 :e28.
  • 4Carden CP, Larkin JM, Rosenthal MA. What is the risk of intracranial bleeding during anti-VEGF therapy?. Neuro Oncol, 2008,10:624-630.
  • 5Stadler WM, Figlin RA, Mcdermott DF, et al. Safety and efficacy results of the advanced renal cellcareinoma sorafenib expanded access program in North America. Cancer,2010,116 : 1272-1280.

同被引文献22

  • 1Bianchi M, Sun M, Jeldres C, et al. Distribution of metastatic sites in renal cell carcinoma: a population-based analysis [ J ] Ann Oncol, 2012, 23 (4) :973-980.
  • 2Gore ME, Hariharan S, Porta C, et al. Sunitinib in metastatic renal cell carcinoma patients with brain metastases[ J] . Cancer, 2011, 117(3) :501-509.
  • 3Kim WH, Kim DG, Han JH, et al. Early significant tumor volume reduction after radiosurgery in brain metastases from renal cell carcinoma results in long-term survival [ J ] Int J Radiat Oneol Biol Phys, 2012, 82(5) :1749-1755.
  • 4Decker DA, Decker VL, Herskovie A, et al. Brain metastases in patients with renal een carcinoma: prognosis and treatment[ J] . J Clin Oneo1,1984, 2(3) :169-173.
  • 5Wronski M, Arbit E, Russo P, et al. Surgical resection of brain metastases from renal cell carcinoma in 50 patients [ J ] . Urology, 1996, 47(2) :187-193.
  • 6Kano H, Iyer A, Kondziolka D, et al. Outcome predictors of gamma knife radiosurgery for renal cell carcinoma metastases [ J ] . Neumsurgery, 2011, 69 (6) : 1232-1239.
  • 7Bastos DA, Molina AM, Hatzoglou V, et al. Safety and Efficacy of Targeted Therapy for Renal Cell Carcinoma With Brain Metastasis[J] . Clin Genitourin Cancer, 2015, 13 (1) : 59-66.
  • 8Sperduto PW, Chao ST, Sneed PK, et al. Diagnosis-specific prognostic factors, indexes, and treatment outcomes for patients with newly diagnosed brain metastases: a multi-institutional analysis of 4259 patients [ J ] 2010, 77(3) :655-661.
  • 9Vogl UM, Bojic M, Lamm W Int J Radiat Oncol Biol Phys et al. Extracerebral metastases determine the outcome of patients with brain metastases from renal cell carcinoma[ J] . BMC Cancer, 2010, 10:480.
  • 10Gutenberg A, Nischwitz MD, Gunawan B, et al. Predictive chromosomal clusters of synchronous and metachronous brain metastases in clear cell renal cell carcinoma[ J] . Cancer Genet, 2014, 207(5) :206-213.

引证文献3

二级引证文献10

中华医学杂志
2013年 第20期

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