中国眼镜蛇毒蛋白酶natrahagin对大鼠血液流变学的影响

Effect of Natrahagin, A Chinese Cobra Venon Proteinase on Hemorrheology in Rat

观察中国眼镜蛇毒蛋白酶natrahagin对大鼠血液流变学和血浆纤维蛋白原水平的影响,发现natrahagin低剂量(0.025mg/kg)、中剂量(0.05mg/kg)以及高剂量(0.1mg/kg)静脉注射后,显著降低200、30、51/S各切变率下大鼠的全血粘度和血浆粘度(P<0.05或P<0.01),对红细胞压积无显著影响(P>0.05),同时可剂量依赖性地降低大鼠血浆纤维蛋白原浓度(P<0.05或P<0.01)。

The effects of natrahagin, a Chinese cobra venom proteinase on hemorrheology and plasma fibrinogen level in rat was investigated. The results showed that intravenous injection of natrahagin (0.025-0.1 mg/kg) dose - dependendy decreased the whole blood viscosity and the plasma viscosity (P<0.05orP<0.01) in rat, but caused no significant effect on hematocrit (P >0.05) . Natrahagin also decreased the plasma fibrinogen level (P<0.05 or P<0.01) of rat in a dose - dependent manner at these doses.