CTOP方案治疗恶性淋巴瘤疗效观察

Effect of CTOP scheme in the treatment of malignant lymphoma

目的:观察CTOP方案治疗恶性淋巴瘤的疗效。方法:应用CTOP方案治疗我院收治的32例恶性淋巴瘤患者,2个疗程后评价疗效。结果:32例恶性淋巴瘤患者,其中弥漫大B细胞淋巴瘤20例,套细胞淋巴瘤6例,T细胞性淋巴瘤4例,伯基特淋巴瘤2例,均为初治病人。予CTOP方案治疗2疗程,结果 CR 50%(16例),PR 25%(8例),总有效率为75%(24例)。毒副反应中骨髓抑制为中度,胃肠道反应轻微。心脏毒性表现为心律失常、ST-T改变等,停药后均可恢复。肝肾毒性轻微。结论:CTOP方案是治疗恶性淋巴瘤的有效方案,可作为一线方案在临床应用。

Objective：To observe the effect of CTOP scheme for malignant lymphoma.Methods：To treat 32 cases of malignant lymphoma patients by CTOP regimen.Results：Of 32 cases of malignant lymphoma there were diffuse large B cell lymphoma 20 cases,6 cases of lymphoma cells,T cell sex lymphoma 4 cases,burkitt lymphoma in 2 cases.CR was 50%（16 cases）,PR 25%（8 cases）,with the total effective rate 75%（24 cases）.Adverse reaction were bone marrow suppression,gastrointestinal reaction,cardiac toxicity.Conclusion：CTOP scheme is effective for malignant lymphoma.