血管内大B细胞淋巴瘤临床病理观察

Intravascular large B-cell lymphoma:a clinicopathological analysis of 2 cases

目的:探讨血管内大B细胞淋巴瘤的临床病理学特点、诊断及其预后。方法:报道2例血管内大B细胞淋巴瘤,对其临床资料、组织学形态及免疫标记结果进行分析,并复习相关文献。结果:2例患者年龄分别为73岁、54岁,临床表现为反复发热。组织学所见,受累组织小血管扩张,管腔内充满异型肿瘤细胞。免疫组化标记,肿瘤细胞CD20(+),CD3(-)。随访1例于发病后2个月死亡,1例于发病后7个月死亡。结论:血管内大B细胞淋巴瘤是一种罕见的非霍奇金淋巴瘤,临床表现缺乏特异性,诊断依靠病理学检查。该肿瘤恶性度极高,患者预后极差。

Objective：To investigate the clinicopathological feature as well as the diagnosis and prognosis of intravascular large B-cell lymphoma（IVLBCL）.Methods：Two cases of IVLBCL were studied on their clinical data,histopathology and immunohistochemistry.Results：The age of two patients were 73 and 54 years old.Both patients presented with fever.Histologically,the lesions consisted of dilated vascular,and the vascular channels were filled with neoplastic cells.Immunohistochemically,the tumor cells were positive for CD20,and negative for CD3.The follow-up revealed that one patient died at 2 months from the date of clinical presentation and another died at 7 months.Conclusion：IVLBCL is a rare variant of non-Hodgkin lymphoma,and the diagnosis is based on histopathology.IVLBCL is with high aggression,and the patients have poor prognosis.