PVP联合雷奈酸锶治疗绝经后骨质疏松性椎体压缩骨折78例

Effect of PVP combined with strontium ranelate treatment on the osteoporotic vertebral compression fractures in 78 patients

目的观察经皮椎体成形术(PVP)联合雷奈酸锶(SrR)治疗骨质疏松性椎体压缩骨折(OVCF)的疗效。方法对绝经后OVCF 78例,行PVP联合SrR治疗。观察患者术后疼痛缓解、骨密度(BMD)、骨代谢指标和不良反应的发生情况。结果所有患者术后疼痛明显缓解,SrR治疗一年后患者髋骨BMD较治疗前显著提高(P<0.05),未见新发骨折。骨代谢指标血清骨钙素(BGP)、总I型前胶原氨基端延长肽(PINP)较SrR治疗前显著增加(P<0.05),β-胶原降解产物(β-Crosslaps)较SrR治疗前显著降低(P<0.05),未发现严重不良反应。结论 PVP联合SrR治疗OVCF疗效肯定。

Objective To observe the effect of percutaneous vertebroplasty （PVP） combined with strontium ranelate （SrR） treatment on the osteoporotic vertebral compression fracture （OVCF）. Methods A total of 78 postmenopausal patients with OVCF received the treatment of PVP combined with SrR. Bone pain, bone mineral density （BMD） , bone metabolism indexes, and the occurrence of adverse effect were observed before and after the treatment. Results Bone pain of all patients was significantly relieved after PVP. After receiving the treatment of PVP combined with SrR for 1 year, BMD of the left femur in all patients was significantly higher than before （P 〈 0.05 ）. And there was no new occurrence of bone fractures. BGP and PINP levels in serum were significantly higher than before （P 〈 0. 05）. On the contrary, β- Crosslaps was significantly lower than before （P 〈 0.05）. No severe adverse effect was observed throughout the whole period. Conclusion The effect of PVP combined with SrR on the treatment of OVCF is definite.