摘要
目的:探讨准分子激光屈光性角膜切削术(photorefractive keratectomy,PRK)联合术中使用0.2g/L丝裂霉素(MMC)矫治高度近视的安全性、有效性、稳定性。方法:对109例201眼高度近视的患者行PRK术,激光切削后使用0.2g/LMMC20s,观察术后角膜上皮愈合时间、观察术后1,3,6,12mo时裸眼视力、矫正远视力、屈光状态、haze形成情况及并发症情况、角膜内皮细胞计数等。结果:角膜上皮愈合时间为3.68±0.35d。术后裸眼视力均有明显提高,术后12mo裸眼视力达到1.0以上的者189眼(94%),等效球镜在±0.5D以内者153眼(76%)。术后矫正远视力下降1行者7眼(3%),无1例矫正远视力下降2行或2行以上。术后3mo与术后12mo相比,屈光度变化≤0.5D者占96%。手术前后角膜内皮细胞计数、变异系数比较均无显著性差异(P1=0.71;P2=0.83)。术后12mo,0～0.5级haze者189眼(94%),1级haze者12眼(6%);未见2级以上haze。术后未见丝裂霉素毒性反应及并发症。结论:准分子激光屈光性角膜切削术联合术中使用0.2g/LMMC20s矫治高度近视安全、有效。
AIM： To evaluate the efficacy, safety and stability of photorefractive keratectomy （PRK） for high myopia with 0.2g/L mitomycin C （MMC）. METHODS： Totally 109 patients （201 eyes） after PRK were treated with intraoperative application of 0. 2g/L MMC for 20 seconds. The recovery of cornea epithelium after surgery was regularly observed. The uncorrected visual acuity （UCVA）, corrected distance visual acuity （CDVA）, refraction, haze, complications and endothelial cell counts 1 month, 3, 6, 12 months after PRK were compared. RESULTS ：The time of corneal epithelium recovery was 3.68±0.35 days. All eyes had a significant increase in UCVA. 12 months after surgery, 189 eyes （94%） achieved UCVA better than 1.0 and 153 eyes （76%） had a spherical equivalent （SE） within±0.5D. 7 eyes （3%） lost one line of CDVA. No one lost 2 or more lines of CDVA. Ninety-six percent eyes changed within ± 0. 5D when comparing 3 month and 12 month. Postoperative endothelial cell density and coefficient of variability（CV） did not show a significant difference from preoperative measurements（P1 = 0.71; P2 = 0. 83）. Haze of grade 1 occurred in 12 eyes （6%） and haze between grade 0.5 and 1 existed in 189 eyes（94%） at 12 months. No eye developed haze over grade 2. No toxic effect and complications of MMC were found after surgery.CONCLUSION. PRK with intraoperative application of MMC for 20 seconds appears to be a safe and effective method for correction of high myopia.
出处
《国际眼科杂志》
CAS
2013年第6期1127-1130,共4页
International Eye Science
