维生素A棕榈酸酯眼用凝胶联合玻璃酸钠滴眼液治疗眼表面损伤

Clinical evaluation of Vitamin A palmitate eye ophthalmic gel combined Ellie eye drops for treatment of eye surface trauma

目的:观察并评价维生素A棕榈酸酯眼用凝胶和玻璃酸钠滴眼液联合应用治疗各种眼表面损伤的临床效果。方法:观察眼表损伤患者167例,随机分成玻璃酸钠滴眼液治疗组45例,维生素A棕榈酸酯眼用凝胶治疗组55例,联合应用组67例。分别应用玻璃酸钠滴眼液滴眼白天每2h1次(6次/d),维生素A棕榈酸酯眼用凝胶治疗组白天每2h1次(6次/d),晚上睡前滴眼1次,联合应用组同时按上述方法两药间隔5min点眼治疗。结果:维生素A棕榈酸酯眼用凝胶治疗组痊愈率和总有效率分别为56.4%和83.6%,玻璃酸钠滴眼液组的痊愈率和总有效率分别为66.7%和88.9%,联合治疗组的痊愈率和总有效率分别为83.6%和97.0%。单独应用玻璃酸钠滴眼液在各种眼表面损伤的有效率优于维生素A棕榈酸酯眼用凝胶,而联合应用组治疗各种眼表面损伤的有效率明显高于单独应用组(P<0.05)。观察过程中未见局部刺激和全身不良反应。结论:玻璃酸钠滴眼液较维生素A棕榈酸酯眼用凝胶治疗各种眼表损伤更有效,但两药联合应用治疗各种眼表面损伤疗效更确切,应用安全。

AIM： To observe and evaluate clinical effect of the combined use of vitamin A palmitate eye ophthalmic gel and Ellie eye drops for the treatment of various eye surface damage. METHODS： Totally 167 cases of corneal disease were randomly divided into Ellie eye drops treatment group （ n= 45）, vitamin A palmitate eye ophthalmic gel （n= 55） in treatment group, the combined use group （n= 67）. Ellie eye drops were used to drop eye every 2 hours a day （daily 6 times）. Vitamin A palmitate eye ophthalmic gel treatment group was used every 2 hours a day （daily 6 times）, eye drops 1 time before sleeping in the evening. The combined use group was treated according to the above method of two medicines with 5 minutes interval. RESULTS： Cure rate and the total effective rate of vitamin A palmitate eye ophthalmic gel treatment group were 56.4% and 83.6% respectively. Cure rate and the total effective rate of Ellie eye drops group were 66.7% and 88.9% respectively. Cure rate and the total effective rate of combined use group were 83, 6% and 97, 0% respectively. Alone use of El surface damage was more palmitate eye ophthalmic gel ie eye drops in various eye efficient than vitamin A . palmitate eye ophthalmic gel. The efficacy of combineduse group for the treatment of various eye surfacedamages was obviously higher than that of the singleapplication group （P〈 0. 05）. Local stimulation andsystemic adverse reactions were not found during the observation. CONCLUSION： Ellie eye drops is more effective than vitamin A palmitate eye ophthalmic gel for the treatment of all kinds of ocular surface damage, but the two medicine combined application treatment is much safer and more specific than the alone application.