腰椎后路融合术后多模式镇痛的安全性和疗效分析

Efficacy and safety of multimodal analgesia in patients after posterior lumbar fusion operation

目的评价多模式镇痛在腰椎后路融合术后的安全性及疗效。方法腰椎后路融合术后患者48例，随机分为口服塞来昔布联合芬太尼PCIA组（试验组）和单纯应用芬太尼PCIA组（对照组），分别记录各组术后48h内VAS评分、芬太尼用量及不良反应。结果与对照组比较，试验组VAS评分、芬太尼用量及不良反应发生率均较低，差异有统计学意义（P〈0．05）。结论口服塞来昔布联合芬太尼PCIA多模式镇痛可缓解腰椎后路融合术后48h内疼痛，减少芬太尼用量，降低不良反应发生率。

Objective To evaluate the safety and efficacy of postoperative multimodal analgesia in patients with posterior lumbar fusion operation. Methods Forty-eight patients undergoing the operation of posterior lumbar fusion were randomly divided into celecoxib combined with fentanyl PCIA group（treatment group） and simple fentanyl PCIA group（control group）. VAS, fentanyl consump- tion and adverse effects rate were recorded during 48 h after the operation. Results VAS, {entanyl consumption and adverse effects rate were significantly lower in the treatment group than those in the control group（P〈0.05）. Conclusion Multimodal analgesia with celecoxib combined with fentanyl PCIA can relieve pain, reduce fentanyl consumption and decrease adverse effects rate for patients af- ter posterior lumbar fusion operation.