期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

局麻药脊髓神经毒性的研究进展 被引量：1

Progress of local anesthetic neurotoxicity in spinal cord
原文传递
导出
摘要 越来越多的实验研究表明局麻药有潜在的神经毒性，脊椎麻醉后神经功能损害可能是由于局麻药的直接毒害作用，但其作用机理尚不清楚。本文就局麻药脊髓神经毒性的研究进展综述如下。 Increasing evidences suggest that local anesthetics are of potentially neurotoxic and that neurologie impairment after spinal anesthesia may result from a direct neurotoxic effect of local anesthetic. However, the mechanism of neurotoxicity of local anesthetics remains unclear. Progress of local anesthetic neurotoxicity on spinal cord is summarized in this paper.
作者 申华素 崔静静 徐贯杰
机构地区 河北医科大学第三医院麻醉科 河北省沧州市中西医结合医院麻醉科
出处 《实用疼痛学杂志》 2013年第1期58-62,共5页 Pain Clinic Journal
关键词 麻醉药 局部 脊髓 神经毒性 Anesthetics, local Spinal cord Neurotoxicity
分类号 R971.1 [医药卫生—药品]
  • 相关文献

参考文献31

  • 1Rigler ML, Drasner K, Krejcie TC, et al. Cauda equina syn drome after continuous spinal anesthesia. Anesth Analg , 1991,72(3) 275-281.
  • 2Schneider M, Ettlin T, Kaufmann M, et al. Transient neuro logic toxicity after hyperbaric subarachnoid anesthesia with 5 lidocaine. Anesth Analg, 1993,76(5) 1154-1157.
  • 3Aguilar J L, Pelaez R. Transient neurological syndrome does it really exist? Curr Opin Anaesthesiol, 2004,17 (5) : 423-426.
  • 4Gozdemir M, Muslu B, Sert H, et al. Transient neurological symptoms after spinal anesthesia with levobupivacaine 5 mg/ ml or lidocaine 20 mg/ml. Acta Anesthesiol Scand, 2010, 54 (1): 59-64.
  • 5Pollock JE, Liu SS, Neal JM, et al. Dilution of spinal lido- caine does not alter the incidence of transient neurologic symp- toms. Anesthesiology, 1999, 90(2)= 445-450,.
  • 6Dahlgren N, Tornebrandt K anaes*hesia. A follow-up of thetics performed over three 1995, 39(7): 872-880. Neurological complications after 18,000 spinal and epidural anaes years. Acta Anaesthesiol Scand,.
  • 7Shi J, Jia L, Yuan W, et al. Clinical classification of cauda equina syndrome for proper treatment. Aeta Orthop, 2010,81(3):391-395.
  • 8Kaneko S, Matsumoto M, Tsuruta S, et al. The nerve root entry zone is highly vulnerable to intrathecal tetracaine in rab- bits. Anesth Analg, 2005, 101(1):107-114.
  • 9Zhong Z, Qulian G, Yuan Z, et al. Repeated intrathecal ad- ministration of ropivacaine causes neurotoxicity in rats. An- aesth Intensive Care, 2009, 37(6): 929-936.
  • 10Takenami T, Wang G, Nara Y, et al. Intrathecally adminis tered ropivacaine is less neurotoxic than procaine, bupivacaine and levobupivaeaine in a rat spinal model. Can J Anaesth 2012, 59(5), 456-465.

二级参考文献11

  • 1Malinovsky JM, Charles F, Baudrimont M, et al. Intrathecal ropivacaine in rabbits: pharmacodynamic and neurotoxicologic study. Anesthesiology,2002, 97:429-435.
  • 2Gautier PE, De Kock M, van Steenberge A, et al. Intrathecal ropiyacaine for ambulatory surgery. Anesthesiology, 1999,91: 1239-1245.
  • 3Levin A, Datta S, Camann WR. Intrathecal ropivacaine for labor analgesia: a comparison with bupivacaine . Anesth Analg, 1998,87: 624-627.
  • 4Yaksh TL, Rudy TA. Chronic catheterization of the spinal subarachnoid space. Physiol Behav, 1976,17:1031-1036.
  • 5Hirsch T, Susin SA, Matzo I, et al. Mitochondrial permeability transition in apoptosis and necrosis. Cell Biol Toxicol, 1998, 14:141-145.
  • 6Kitagawa N, Shimohama S, Oeda T, et al. The role of the presenilin-1homologue gene sel-12 of caenorhabditis elegans in apoptotic activities. J Biol Chem, 2003,278:12130-12134.
  • 7Iida H,Ohata H, Iida M. Attenuated additional hypocapnic constriction,but not hypercapnic dilation, of spinal pial arterioles during spinal ropivacaine. Anesth Analg, 1999,89:1510-1513.
  • 8Freedman J, Post C, Kahrstrom J, et al. Vasoconstrictor effects in spinal cord of the substance P antagonist [ D-Arg,D-Trp 7,9 Lell]-substance P(Spantide) and somatostatin and interaction with thyrotropin releasing hormone. Neuroscience, 1988,27: 267-278.
  • 9Malinovsky JM, Pinaud M. Neurotoxicity of intrathecally administrated aqents . Ann Fr Anesth Reanim, 1996,15: 647-658.
  • 10Kalichman MW, Myers RR. Behavioral and electrophysiological recovery following cryogenic nerve injury. Exp Neurol, 1987, 96:692-702.

共引文献49

同被引文献1

引证文献1

二级引证文献3

实用疼痛学杂志
2013年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部