血清前白蛋白对肝功能评估的研究进展

New advances in the use of serum prealbumin as an index of liver function

血清前白蛋白(prealbumin,PA)主要由肝脏合成,可反映肝脏合成及储备能力及营养状况,具有检测方便、准确、干扰因素少等优点.长期以来由于一直把血清PA以独立因素作为肝脏功能状态的评价指标,缺乏以一种系统、关联、前瞻的临床思维方法去分析血清PA,虽然临床应用由来已久,但是广大临床医生在肝病的诊治过程中仍不足以重视血清PA的变化特点,作者结合近年来对血清PA生化特性、结构、功能新变化以及与血清白蛋白、胆固醇、胆碱酯酶、总胆汁酸、凝血酶原时间、肝功能评分及终末期肝病模型评分系统等指标相关性研究作一综述.

Serum prealbumin, mainly synthesized in the liver, can be used to assess the function of liver protein synthesis, reserve and nutritional status with many advantages such as convenience, accuracy and fewer interference factors; however, it is clinically used often as an independent factor, and there is little systematic, relevant and prospective research on it. Although serum prealbumin test has been used for a long time, many clinicians do not attach great importance to the characteristics of changes in serum pre- albumin. In this paper, we will review new characteristics of biochemistry structure and function of serum prealbumin, and relevance between serum prealbumin and serum albumin, cholesterol, cholinesterase, total bile acids, pro- thrombin time, Child-Turcotte-Pugh, and model of end-stage liver stage.