5-甲基吡嗪-2-羧酸的合成研究

Synthisis of 5-methylprazine-2-carboxylic acid

目的 :研究 5 甲基吡嗪 2 羧酸的合成方法。方法 :以 2 ,5 二甲基吡嗪和N 氯代琥珀酰亚胺为原料 ,经氯代、酯化、碱解、氧化四步反应合成 5 甲基吡嗪 2 羧酸。结果 :合成的 5 甲基吡嗪 2 羧酸的总收率为 52 .0 % ,结构经元素分析 ,MS ,1HNMR确证。结论 :设计的合成路线合理 ,反应条件温和 ,收率高 ,适合于工业生产。

OBJECTIVE:To synthesize 5 methylpyrazine 2 carboxylic acid.METHOD:5 methylpyrazine 2 carboxylic acid was synthesized from 2,5 dimethylpyrazine and N chlorosuccinimide by chlorinating,esterification,alkalisis and oxidation.RESULTS:The yield of the 5 methylpyrazine 2 carboxylie acid was 52.0%.The final product was identified by element analysis,MS and 1HNMR.CONCLUSION:This is a good way to produce 5 methylpryrazine 2 carboxylic acid with the mild condition and a relative high yield.