定期CT扫描筛查发现的非小细胞肺癌对患者肿瘤内分泌指标的临床分析

Clinical analysis of tumor endocrine indicators of patients with nonsmall cell lung cancer detected by regular CT scan screening

目的探讨定期CT扫描筛查发现的非小细胞肺癌患者的肿瘤内分泌情况。方法回顾性研究非小细胞肺癌患者的临床资料,分为观察组(通过定期接受CT扫描筛查发现病变)和对照组(未定期接受CT扫描),检测患者肿瘤组织中VEGFA、VEGFB及其受体VEGFR1的mRNA和蛋白水平,并通过单因素回归分析肿瘤内分泌指标与肿瘤TNM分期的相关性。结果观察组患者肿瘤组织中VEGFA、VEGFB、VEGFR1的蛋白和mRNA含量明显低于对照组,且VEGFA、VEGFB、VEGFR1的水平与TNM分期呈正相关。结论多层螺旋CT早期诊断的非小细胞肺癌患者体内VEGFA、VEGFB、VEGFR1的含量较低,TNM分期较好,对于疾病的早期诊断和治疗具有积极意义。

Objective To study the tumor endocrine conditions of patients with non-small cell lung cancer detected by regular CT scan screening. Methods Clinical information of patients with non-small cell lung cancer was analyzed retrospectively. The patients were divided into the observation group with the lesion detected by regular CT scan screening and the control group not receiving regular CT scan. The mRNA and protein levels of VEGFA and VEGFB and their receptor VEGFR1 in the patient＇s tumor tissue were detected,The correlation between the tumor endocrine indicators and the tumor TNM sating was analyzed using the univariate regression analysis. Results The mRNA and protein levels of VEGFA and VEGFB and VEGFR1 of the observation group were significantly lower than those of the control group and the levels of VEGFA, VEGFB and VEGFR1 were positively correlated to the TNM staging. Conclusion The patients with early non-small cell lung cancer diagnosed by multi-slice CT had relatively low VEGFA, VEGFB and VEGFR1 content and good TNM staging, which is of positive significance for the early diagnosis and treatment of disease.