前列地尔联合甲钴胺治疗糖尿病周围神经病变的疗效分析

Analysis of efficacy of alprostadil combined with methylcobalamin in the treatment of diabetic peripheral neuropathy

目的探讨前列地尔联合甲钴胺治疗糖尿病周围神经病变(DPN)的临床疗效。方法入组70例DPN患者随机分为两组,治疗组36例患者接受前列地尔联合甲钴胺治疗,而对照组34例患者仅接受甲钴胺治疗。结果治疗组总有效率为94.44%,远高于对照组的52.94%(P<0.05)。治疗组治疗后正中神经、尺神经、胫神经MNCV、SNCV均显著高于对照组(P<0.05)。两组均未见严重毒副反应发生。结论前列地尔联合甲钴胺治疗DPN疗效较好。

Objective To evaluate the clinical efficacy of alprostadil combined with methylcobalamin in the treatment of diabetic peripheral neuropathy （DPN）. Methods Seventy patients with DPN were divided into 2 group, 36 patients of the treatment group received the alprostadil combined with mecobalamin, while 34 patients of the control group only received mecobalamin. Results The total response rate of the treatment group （94.44%） was far higher than that of the control group （52.94%）（P 〈 0.05）.After the treatment, the MNCV and SNCV of median nerve,ulnar nerve and tibial nerve in the treatment group were than those of the control group （P 〈 0.05）.No serious toxicity was in all the patients of 2 groups. Conclusion Alprostadil combined with methylcobalamin is effect for the patients with DPN.