DCA降低家兔血乳酸值的实验研究

Experimental study of DCA reducing lactic acid content in rabbits blood

目的 :为研究Dichloroacetate(DCA)降低血乳酸的疗效。方法 :采用作者改良的BarKer氏法观测正常及高乳酸血症 (HLA)家兔血乳酸值在接受DCA后的动态变化。结果 :静脉注射DCA( 50mg/kg)后 1 5及 3 0min时 ,正常 (P<0 .0 5)与HLA家兔血乳酸值 (P <0 .0 1 )均显著下降。结论 :DCA具有降低血乳酸的作用。

OBJECTIVE:To study the therapeutic effect of DCA to decrease blood lactic acid.METHOD:The dynamic changes of blood lactic acid in normal and lacticemia rabbits were observed after DCA was administrated by BarKer′s method(ameliorated by us).RESULTS:DCA(50mg/kg) declined blood lactic acid content in lacticemia(P< 0.01 ) and normal rabbits(P<0.05) after the intravenous injection of DCA for 15 or 30 minutes.CONCLUSION:DCA has the action to decrease blood lactic acid.