血液灌流联合连续性静脉-静脉血液滤过治疗尿毒症脑病的临床研究

The clincal research of hemoperfusion combined with continuous venous-venous hemofiltration in treatment uremia encephalopathy

目的:研究血液灌流联合连续性静脉-静脉血液滤过治疗尿毒症脑病的临床疗效。方法:针对我院21例尿毒症脑病患者采取血液灌流联合连续性静脉-静脉血液滤过治疗方案。观察患者治疗后的临床疗效以及实验室各项指标。结果:CVVH+HP治疗中患者意识逐渐好转,症状减轻,治疗后临床疗效评定较治疗前有明显改善;治疗前后血压、心率变化无显著差异(P>0.05);APACHE Ⅱ评分逐渐下降,较治疗前有显著性差异(P<0.01);患者肾功明显改善(P<0.05),清除中、大分子的能力较好,具有显著统计学意义。结论:CVVH+HP能够明显改善患者临床症状且血流动力学稳定,患者血压、心率治疗前后无明显波动,大大降低了血液净化的风险,值得临床推广。

Objective： To investigate the effect of hemoperfusion combined with continuous venous-venous hemofiltrationln treatment uremia encephalopathy. Methods： 21 cases had been treated with hemoperfusion combined with cntinuous venous-venous hemofihration . To observe the clinical effieacy and laboratory tests. Results： Consciousness recovery by degreen. The changes had no statistical signif- icance in blood pressue and heart rate. The stores of APACHEⅡ and the kendey funeation decreased than before treatment. Conclu- sion： The treatment of CVVH ＋ HP can improved the UE.