川芎嗪治疗闭塞性动脉硬化症及其对血管内皮细胞作用的临床观察

Effect of Ligustrazine Injection on Vascular Endothelial Cell of the Patients with Arteriosclerosis Obliterans

目的：通过观察川芎嗪对血管内皮细胞的影响，探讨其治疗闭塞性动脉硬化症的疗效机理。探索从中药中寻找有效的血管保护剂的新途径。方法：使用川芎嗪治疗闭塞性动脉硬化症46例（治疗组），观察患者治疗前后循环内皮细胞的数量，同期观察53名健康人的循环内皮细胞数量，并进行对比。结果：治疗组近期治愈21例（45．7％），显效17例（36．9％），有效8例（17．4％）。治疗前循环内皮细胞数量为（4．39±1．76）个／0．9μl，明显高于健康人组〔（1．53±0．42）个／0.9μl〕，治疗后随着临床症状和体征的好转，循环内皮细胞数下降为（2．43±0．87）个／0．9μl（P＜0．01）。结论：川芎嗪治疗闭塞性动脉硬化症不仅疗效显著，而且对血管内皮细胞损伤也有较好的治疗作用。

Objective: To study the effect of ligustrazine injection (LI) on vascular endothelial cell of the patients with arteriosclerosis obliterans (ASO) and explore the new pathway of investigating effective vascular protective a gents in Chinese medicinal herbs. Methods: Forty-six patients with ASO in the LI group treated by LI were ob served, their circulatlng endothelial cells (CEC) were detected quantitatively before and after treatment. The re sults were compared with the CEC of 53 cases of healthy persons (control group) in the same period. Results: In the LI group, the immediate cure rate was 45. 7 % (21 cases), markedly effective rate 36. 9 % (17 cases) and the effective rate 17. 4 % (8 cases). The CEC of patients before treatment was 4. 39 ±1. 76/0. 9μl, which was significantly higher than that of the healthy persons (1. 53 ± 0. 42/0. 9μl). It could be reduced after treatment,along with the improvement of symptoms and signs, to 2. 43 ± 0. 87/0. 9μl, P < 0. 01. Conclusion: LI in treat ing ASO not only displays extraordinary effect, but also has good effect in curing the damage of endothelial cells.