中药配合同步放、化疗对晚期非小细胞肺癌的影响

Clinical Study on Treatment of Advanced Non-Small Cell Lung Cancer with Chinese Herbal Medicine Combined with Synchronous Radio-and Chemotherapy

目的：探讨中药辨证治疗配合同步放、化疗对晚期非小细胞肺癌（NSCLC）的影响。方法：对56例（A组）晚期NSCLC患者采用中医辨证治疗加同步放、化疗，并与44例同步放、化疗（B组）及34例放、化疗（C组）进行对照，结果：A、B、C组近期有效率分别为87．5％、84．1％、55．9％，A、B两组优于C组（P＜0．01）；中位生存期A组为16．4个月，B组为11．8个月，C组为10．6个月；2、3年生存率A组明显高于B组（P＜0．05），且A组患者临床症状变化、卡氏评分、免疫功能明显改善（P＜0．05，P＜0．01）。结论：中药配合同步放、化疗对晚期NSCLC患者的免疫功能，生存质量，延长生存时间均优于单纯同步放、化疗及放、化疗。

Objective: To explore the effect of applying Chinese herbal medicine according to Syndrome Differentiation of TCM combined with synchronous radio- and chemotherapy (combination therapy) in treating advanced non small cell lung cancer (NSCLC). Methods: The 56 patients in the group A were treated with combination ther apy, and the 44 patients in the group B treated with synchronous radio- and chemotherapy, while the 34 pa tients in the group C treated with non-synchronous radio- and chemotherapy. The efficacy of treatment in the three groups were observed and compared. Results: The immediate effective rate in the A, B, C groups was 87.5%, 84. 1% and 55. 9% respectively, that in the group A and B was better than that in the group C (P< 0.01). The median survival time in the three groups was 16. 4, 11. 8 and 10. 6 months respectively. The 2-year and 3-year survival rate in the group A were markedly higher than those in the group B (P<0.05), moreover, the clinical symptoms, Karnovsky scoring and immune function were obviously improved in the group A (P< 0. 05, P<0. 01). Conclusion: Effect of the combination therapy is superior to that of synchronous radio- and chemotherapy alone in improving immune function, elevating quality of life and prolongating survival time of pa tients with NSCLC.