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肺癌INK4a/ARF基因缺失与突变研究进展 被引量：7

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摘要 INK4a/ARF基因位于人第9号染色体短臂2区1带(9p21),是近期发现的新型抑癌基因,其编码产物分别为p16^(INK4a)和p14^(ARF),它们在细胞增殖周期中起负调控作用 本文综述了肺癌INK4a/ARF基因的结构和功能状态,提示该基因异常是肺癌的又一重要分子标志。肺癌INK4a/ARF基因功能的失活,与该基因位点的纯合或杂合缺失。
作者 胡义德 高楠 曹世龙
机构地区 医大学附属新桥医院全军呼吸内科研究所 上海医科大学附属肿瘤医院放射治疗科
出处 《国外医学（呼吸系统分册）》 2000年第2期102-103,共2页 Section of Respiratory System Foreign Medical Sciences
关键词 肺癌 INK4a/ARF基因 基因缺失 基因突变
分类号 R734.2 [医药卫生—肿瘤]
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同被引文献48

  • 1向国林,朱声荣,陈卫民,陶学金,汤国雄,蔡传宝.COX-2、cyclinD_1在多形性腺瘤和癌在多形性腺瘤中的表达及意义[J].临床口腔医学杂志,2007,23(3):131-134. 被引量：7
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  • 7Nicholson SA,Okby NT,Khan MA, et al. Alterations of p14ARF,p53,and p73 genes involved in the E2F-1-mediated apoptotic pathways in non-small cell lung carcinoma[J]. Cancer Res,2001,61(14) :5636-5643
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国外医学（呼吸系统分册）
2000年 第2期

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