冠状动脉粥样硬化性心脏病患者择期支架植入术前血浆超敏C反应蛋白水平对术后6个月支架内再狭窄及12个月急性冠脉事件发生的预测价值

Prognostic role of preoperative plasma high sensitivity C-reactive protein levels on in-stent restenosis in 6-months and acute clinical outcomes in 12-months after selective stent implantation operation of coronary artery disease

目的 探讨冠状动脉粥样硬化性心脏病（简称冠心病）患者支架植入术前血浆超敏C反应蛋白（hs-CRP）水平与术后6个月支架内再狭窄及12个月急性冠脉事件发生的关系.方法 选择2007年10月～2010年2月我院住院的行经皮冠状动脉介入治疗（PCI）的冠心病患者358例,通过测定支架植入术前患者血浆hs-CRP水平,初步采用Logistic回归分析冠心病患者术前hs-CRP水平和PCI术后6个月后支架内再狭窄和随访12个月急性冠脉事件发生的关系.结果 血浆hs-CRP水平和PCI术后随访12个月急性冠脉事件高度相关（OR=2.21,P ＜0.01）；血浆hs-CRP水平和PCI术后6个月支架内再狭窄无明显相关（OR=1.17,P ＞0.05）.结论 冠心病患者支架植入术前血浆hs-CRP水平和PCI术后急性冠脉事件的发生密切相关,但是和PCI术后支架内再狭窄无明显相关,支架植入术前血浆hs-CRP水平对PCI术后急性冠脉事件的发生有较好的预测价值.

Objective To assess correlation of plasma high sensitivity C-reactive protein （hs- CRP） levels with in-stent restenosis in 6 months and acute coronary outcome in 12 months after PCI. Methods We selected 358 patients with coronary artery disease who were accomplished coronary stent implantation. In the present research, we assayed plasma levels of hs-CRP and other clinic indexes, and we analyzed the association of plasma hs-CRP levels with in-stent restenosis and acute coronary outcome by logistic regression analysis. Results By logistic regression,we get OR of hs-CRP levels to acute coronary outcome（ OR = 2.21 ,P 〈 0.01 ） ; OR of hs-CRP levels to in-stent restenosis（ OR = 1.17 ,P 〉 0.05 ）. Con- clusion There is strong association among plasma hs-CRP levels and acute coronary outcome after PCI, but we have found no relation between plasma hs-CRP levels and in-stent restenosis after PCI. Hs-CRP could not be a prognostic marker of in-stent restenosis after PCI, but could predict future acute coronary outcome after PCI.