期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

炎症反应在慢性心力衰竭中的作用研究进展 被引量：8

下载PDF
导出
摘要 慢性心力衰竭是多种心血管疾病共同的主要死亡原因，除已知的肾素-血管紧张素-醛固酮系统、交感神经系统兴奋性增高和多种内源性神经内分泌激活外，近年研究发现，炎症反应长期、慢性激活可导致左心室收缩功能障碍、促进心室重塑、内皮功能障碍、加重心肌损伤和心功能恶化，并与贫血、恶病质、抑郁等并发症的发生密切相关。我们就炎症反应在慢性心力衰竭病理改变和并发症中的作用进展进行综述。
作者 常文静 蔡辉
机构地区 江苏南京省南京中医药大学第一临床医学院 南京军区南京总医院中西医结合科
出处 《临床内科杂志》 CAS 2013年第5期358-360,共3页 Journal of Clinical Internal Medicine
关键词 心力衰竭 慢性 炎症反应 左心室收缩功能障碍 心室重塑 内皮功能障碍 并发症
分类号 R541.6 [医药卫生—心血管疾病]
  • 相关文献

参考文献19

  • 1Kalogeropoulos AP, Georgiopoulou VV, Butler J. From risk factors to structural heart disease:the role of inflammation. Heart Fail Clin,2012,8:113-123.
  • 2Valgimigli M, Ceconi C, Malagutti P, et al. Tumor necrosis factor-alpha receptor 1 is a major predictor of mortality and new-onset heart failure in patients with acute myocardial infarction: the Cytokine-Activation and Long-Term Prognosis in Myocardial Infarction (C-ALPHA) study. Cir- culation ,2005,111:863-870.
  • 3Chrysohoou C, Pitsavos C, Barbetseas J, et al. Chronic systemic inflam- mation accompanies impaired ventricular diastolic function, detected by Doppler imaging,in patients with newly diagnosed systolic heart failure ( Hellenic Heart Failure Study). Heart Vessels ,2009,24:22-26.
  • 4Kawano S, Kubota T, Monden Y, et al. Blockade of NF-kappaB improves cardiac function and survival after myocardial infarction. Am J Physiol Heart Circ Physio1,2006,291 : H1337-H1344.
  • 5Frantz S,Hu K,Bayer B,et al. Absence of NF-kappaB subunit p50 im- proves heart failure after myocardial infarction. FASEB J, 2006,20: 1918-1920.
  • 6Orn S,Manhenke C, Ueland T, et al. C-reactive protein,infarct size, mi- crovascular obstruction, and left-ventricular remodelling following acute myocardial infarction. Eur Heart J,2009,30 : 1180-1186.
  • 7Pasqui AL, Di Renzo M, Maffei S, et al. Pro/Anti- inflammatory cytokine imbalance in postischemic left ventricular remodeling. Mediators ln- flamm,2010,2010:974694.
  • 8Nagai T, Anzai T, Kaneko H, et al. C-reactive protein overexpression ex- acerbates pressure overload-induced cardiac remodeling through en- hanced inflammatory response. Hypertension, 2011,57 : 208-215.
  • 9Sun M, Chen M, Dawood F, et al. Tumor necrosis factor-alpha mediates cardiac remodeling and ventricular dysfunction 'after pressure overload state. Circulation ,2007,115 : 1398-1407.
  • 10Jobe LJ, Melendez GC, Levick SP, et al. TNF-alpha inhibition attenuates adverse myocardial remodeling in a rat model of volume overload. Am J Physiol Heart Circ Physiol,2009,297 :H1462-H1468.

二级参考文献9

  • 1Anker SD,Ponikowski P,Varney S,et al.Wasting as independent risk factor for mortality in chronic heart failure[J].Lancet,1997,349:1050-1053.
  • 2Prabhu SD,Chandrasekar B,Murray DR,et al.3-Adrenergic blockade in developing heart failure:effects on myocardial inflammatory cytokines,nitric oxide,and remodeling[J].Circulation,2000,101:2103 -2109.
  • 3Deten A,Volz HC,Holzl A,et al.Effect of propranolol on cardiac cytokine expression after myocardial infarction in rats[J].Mol Cell Biochem,2003,251:127-137.
  • 4Anker SD,Sharma R.The syndrome of cardiac cachexia[J].Int J Cardiol,2002,85:51 -66.
  • 5Brink M,Anwar A,Delafontaine P.Neurohormonal factors in the development of catabolic/anabolic imbalance and cachexia[J].Int J Cardiol,2002,85:111-121.
  • 6Conraads VM,Bosmans JM,Vrints CJ.Chronic heart failure:An example of a systemic chronic inflammatory disease resulting in cachexia[J].Int J Cardiol,2002,85:33-49.
  • 7Sharma AM,Pischon T,Hardt S,et al.Hypothesis:Beta-adrenergic receptor blockers and weight gain:a systematic analysis[J].Hypertension,2001,37:250-254.
  • 8Hryniewicz K,Androne AS,Hudaihed A,et al.Partial reversal of cachcxia by beta-adrenergic receptor blocker therapy in patients with chronic heart failure[J].J Card Fail,2003,9:464 -468.
  • 9王晓明,李源,李慧芳,臧益民,贾国良.心力衰竭患者血清中TNF-α,IL-1及IL-6的变化及培哚普利对其影响[J].心脏杂志,2002,14(4):318-320. 被引量：10

同被引文献92

  • 1胡大一.心血管疾病和精神心理障碍的综合管理——“双心医学”模式的探索[J].中国临床医生杂志,2006,34(5):2-3. 被引量：311
  • 2闫晋康,贾竹叶.老年慢性心力衰竭病人的病因及临床特征分析[J].中西医结合心脑血管病杂志,2007,5(1):83-83. 被引量：6
  • 3陈炎,陈亚蓓,陶荣芳.2010急性心力衰竭诊断和治疗指南解读[J].中国医药,2011,6(z1):52-54.
  • 4Ho KK, Anderson KM, Kannel WB, et al. Survival after the onse of congestive heart failure in Framingham Heart Study subjects [ J]. Circulation, 1993,88 ( 1 ) : 107-115.
  • 5Malkin C J, Pugh PJ, Jones RD, et al. The effect of testosterone replacement on endogenous inflammatory cytokines and lipid profiles in hypogonadal men [ J ]. J Clin Endocrinol Metab, 2004, 89(7) :3313-3318.
  • 6Pugh PJ, English KM, Jones TH, et al. Testosterone: a natural tonic for the failing heart [ J]. QJM ,2000,93 (10) :689-694.
  • 7Malkin CJ,Pugh PJ, West JN, et al. Testosterone therapy in men with moderate severity heart failure: a double-blind randomized placebo controlled trial [ J ]. Eur Heart J,2006,27 (1) :57-64.
  • 8Pugh P J, Jones TH, Channer KS, et al. Acute haemodynamic effects of testosterone in men with chronic heart failure [ J]. Eur Heart J, 2003,24(10) :909-915.
  • 9Ceconi C, Boraso A, Mele D, et al. TNFalpha in patients with congestive heart failure [J]. Basic Res Cardiol,2004,99 (1):12- 17.
  • 10Ducharme A, Frantz S, Aikawa M, et al. Targeted deletion of matrix metalloproteinase-9 attenuates left ventficular enlargement and collagen accumulation after experimental myocardial infarction [ J ]. J Clin Invest, 2000,106 ( 1 ) :55-62.

引证文献8

二级引证文献62

临床内科杂志
2013年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部