感觉性受体TRPV1在女性膀胱过度活动症患者膀胱尿路上皮中的表达及临床意义

Expression and clinical significance of transient receptor potential vanilloid type 1 in female patient with overactive bladder

目的 检测女性膀胱过度活动症（OAB）患者膀胱尿路上皮中瞬时电位香草酸受体亚型1（TRPV1）的表达,以期探讨TRPV1在女性OAB患者中的临床意义.方法 采用免疫组织化学SABC法,分别检测21例女性OAB患者膀胱尿路上皮和9例正常女性膀胱尿路上皮中TRPV1的表达,以平均光密度表示其相对含量,并结合临床尿流动力学资料进行分析.结果 TRPV1在女性OAB患者膀胱尿路上皮中的表达明显高于正常膀胱尿路上皮,其平均光密度值分别为0.4834±0.1252与0.3658±0.1009,两者比较差异有统计学意义（P＜0.05）;将女性OAB患者的临床尿流动力学参数值分别与正常女性参考值进行比较,相关参数差异有统计学意义（P＜0.05）.结论 女性OAB患者膀胱尿路上皮中TRPV1高度表达与OAB的发生发展密切相关,提示膀胱敏感性增高在女性OAB的发病机制中具有重要作用.

Objective To detect the expression of transient receptor potential vanilloid type 1 （TRPV1） receptor in female overactive bladder（OAB） patients and investigate its clinical significance. Methods The expression of TRPV1 in 21 cases of the female OAB patients and 9 cases of normal bladder was detected by immunohistochemistry SABC assay, and the intensity of TRPV1 expression was quantified by average optical density（AOD） ;The two groups were compared in terms of AOD values and urodynamic data. Results The TRPV1 expression in OAB patients was significantly higher than that in normal bladder （0.4834 ± 0. 1252 vs. 0. 3658 ± 0. 1009, P 〈 0.05 ）. Significant difference was found between the female OAB patients and the healthy women in the urodynamics parameters. Conclusion The high level of TR- PV1 expression may involve in the development of the female OAB,which indicates that the bladder hypersensitivity may play an important role in the pathogenesis of female OAB.