氯沙坦与培哚普利治疗急性心肌梗死泵功能不全近期疗效观察

Observation of efficacy of losartan versus perindopril in acute myocardial infarction patients complicated with pump failure

目的：评价氯沙坦对急性心肌梗死泵功能不全患者的治疗作用。方法：79例急性心肌梗死并泵功能不全患者随机分为氯沙坦组（A组）和培哚普利组（B组），在按急性心肌梗死基本治疗方案的基础上，A组加用氯沙坦50mg，每日1次，B组加用培哚普利2～4mp，每日1次。观察4周。结果：氯沙坦治疗急性心肌梗死患者泵功能不全与培哚普利相似，减少心律失常发生率的作用及不良反应优于培哚普利。结论：氯沙坦是治疗急性心肌梗死泵功能不全的有效药物。

Objective: To evaluate the efficacy of Losartan in the treatment of AMI patients complicated with pump failure.Methods:79 cases were randomized divided into two group.On the base treatment of acute myocardial infarction,patients in group A were given Losartan 50mg daily while perindopril 2mg to 4mg daily in group B. The course of study was 4 weeks. Results: The clinical efficacy of Losartan were similar to perindopril in AMI patients complicated with pump failure,with a lower incidence of adverse effect than control. Conclusion: This study verified that Losartan is a effective drug in the treatment of AMI complicatedwith pump failure.